The role of Gas6 in endothelial cell (EC) function remains incompletely characterized. Here we report that Gas6 amplifies EC activation in response to inflammatory stimuli in vitro. In vivo, Gas6… (More)
The plasminogen system plays an important role in the proteolytic degradation of extracellular matrices during wound healing. In the present study we investigated the impact of the plasminogen system… (More)
OBJECTIVES
Inflammatory macrophage apoptosis is critical to atherosclerotic plaque formation, but its mechanisms remain enigmatic. We hypothesized that inhibitor of apoptosis protein (IAP) survivin… (More)
BACKGROUND
Understanding atherogenesis will benefit significantly from simultaneous imaging, both ex vivo and in vivo, of structural and functional information at the (sub)cellular level within… (More)
INTRODUCTION
Radiofrequency (RF) is the most commonly used energy source for the treatment of cardiac arrhythmias. Surgical experience has shown that cryoablation also is effective for ablating… (More)
Seppo Ylä-Herttuala1*, Jacob Fog Bentzon2, Mat Daemen3, Erling Falk2, Hector M. Garcia-Garcia4, Joerg Herrmann5, Imo Hoefer6, Suvi Jauhiainen7, J. Wouter Jukema8, Rob Krams9, Brenda R. Kwak10,… (More)
OBJECTIVE
Adhesive interactions between cells and the extracellular matrix play an important role in inflammatory diseases like atherosclerosis. We investigated the role of the collagen-binding… (More)
BACKGROUND
This study documents (1) the progression of atherosclerosis along the entire arterial tree in APOE*3-Leiden mice after 1, 4, 6, 9, and 12 months of a high-fat/high-cholesterol (HFC) diet… (More)
The presence of human cytomegalovirus (HCMV) nucleic acids was demonstrated in almost all major arteries of HCMV-seropositive patients by polymerase chain reaction. The amount of HCMV nucleic acids… (More)
Biomarkers for primary or secondary risk prediction of cardiovascular disease (CVD) are urgently needed to improve individual treatment and clinical trial design. The vast majority of biomarker… (More)