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Apolipoprotein E (apoE) is a 34-kD protein with multiple biological properties. Recent clinical and preclinical observations implicate a role for apoE in modifying the response of the brain to focal and global ischemia. One mechanism by which apoE might exert these effects is by reducing glutamate-induced excitotoxic neuronal injury associated with ischemic(More)
Oxidative stress is known to play an important role in the response of brain to traumatic insults. We tested the hypothesis that increased extracellular superoxide dismutase (EC-SOD) expression can reduce injury in a mouse model of closed head injury. Neurologic, cognitive, and histologic outcomes were compared between transgenic mice exhibiting a fivefold(More)
To decide the application of tricalcium phosphate (TCP)to periodontal therapy, following fundamental studies on TCP were performed. Materials used were six kinds of TCPs of which firing temperature were 900 • Ž(LT)and 1,100 • Ž (HT), and diameter were less than 100,um(size S), 200 • `300,ƒÊm(size M)and 500 • `1,000,um(size L). To investigate the surface(More)
UNLABELLED Minimum alveolar anesthetic concentration (MAC) is defined as an end-tidal concentration of inhaled anesthetic required to prevent purposeful movement (positive motor response) in 50% of subjects to somatic noxious stimuli. Although MAC for visceral noxious stimuli has not been well investigated, airway occlusion can be a noxious respiratory(More)
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