Massimo Tocchini

Learn More
PURPOSE The commercial availability of zoledronic acid, a third generation bisphosphonate, prompted us to evaluate the modifications in angiogenic cytokines levels after a single i.v. infusion of this drug. EXPERIMENTAL DESIGN Thirty consecutive cancer patients with scintigraphic and radiographic evidence of bone metastases were treated with a single(More)
Three groups of ten lactating Sardinian ewes were used between 3 and 6 month of lactation to determine the effects of supplementing diets with n-3 fatty acids on milk production and milk fat composition. The control group (A) was fed on a mixture of Gramineae hay with a pelleted alfalfa and concentrate; the other groups (B and C) were given the control(More)
We studied 56 patients affected by primary hypercholesterolemia treated with placebo for 1 month and with simvastatin (20 mg/day) or pravastatin (20 mg/day) for 6 months during a double-blind clinical trial. At 1-month intervals we determined the following parameters in the serum: total and HDL cholesterol, triglycerides, and apolipoprotein A-1 and B. At(More)
The analysis of urinary enzymes levels in renal parenchyma involves noninvasive test to evaluate possible renal damage. This laboratory method is useful for establishing the extent of renal damage, distinguishing between lower and upper urinary tract infections, and determining the nephrotoxicity of drugs. We are currently investigating NAG and AAP which(More)
BACKGROUND Thiopental is an anaesthetic drug that is largely used in both short-term and long-term infusion. After long-term infusion of thiopental, non-linear and inter-individual-dependent pharmacokinetics occur because of the saturation and/or induction of the metabolism. Clinical monitoring is important so that therapeutic adjustments can be made in(More)
Osteopontin (OPN) is a multifunctional glycophosphoprotein secreted by many cell types, including osteoblasts, lymphocites, macrophages, epithelial cells, and vascular smooth muscle cells. It has been implicated in many physiological and pathological processes, such as cell-mediated immunity, inflammation, cell survival, and tumor invasion and metastasis.(More)