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Diabetic patients are at higher risk of developing physical disabilities than non-diabetic subjects. Physical disability appears to be related, at least in part, to muscle dysfunction. Several studies have reported reduced muscle strength and power under dynamic and static conditions in both the upper and lower limbs of patients with type 2 diabetes.(More)
Muscle fiber conduction velocity (MFCV) gives critical information on neuromuscular control and can be considered a size principle parameter, being suggestive of motor unit recruitment strategies. MFCV has been recently measured during constant-load sub-maximal cycling exercise and was found to correlate positively with percentage of type I myosin heavy(More)
OBJECTIVE The aim of this study was to compare the optimal vibration frequency (OVF), which corresponds to maximal electromyographic muscle response during whole-body vibration, between young, middle-aged, and older women in four muscles of the lower-limbs. DESIGN OVF was measured as the frequency corresponding to maximal root mean square of the surface(More)
INTRODUCTION In this study we tested the hypothesis that caffeine supplementation improves neuromuscular function, which has both nutritional and clinical relevance. METHODS Fourteen male subjects (mean ± SD: 23.8 ± 2.8 years) volunteered in a double-blind, repeated-measures study with placebo (PLA) or caffeine (CAFF) (6 mg kg(-1)). Maximal voluntary(More)
Atherosclerosis-related cardiovascular disease and diabetes mellitus are leading causes of mortality in the world and both disorders are closely related to the postprandial phenomena. Regular exercise is being strongly advocated as a precious tool in easing the global burden of chronic disease. Although exercise intensity, duration and frequency are well(More)
OBJECTIVE We investigated mitochondrial DNA (mtDNA) variants in children with a first episode of acquired demyelinating syndromes (PD-ADS) of the CNS and their relationship to disease phenotype, including subsequent diagnosis of multiple sclerosis (MS). METHODS This exploratory analysis included the initial 213 children with PD-ADS in the prospective(More)
PURPOSE The purpose of this study was to investigate the effect of diabetes, motor nerve impairment, and training status on neuromuscular function by concurrent assessment of the torque-velocity relationship and muscle fiber conduction velocity (MFCV). METHODS Four groups were studied (n = 12 each): sedentary patients with diabetes in the first (lower)(More)
Many studies have highlighted the importance of physical activity (PA) for health, and recent evidence now points to the positive improvements associated with exercise in type 2 diabetes mellitus (T2DM). However, few physicians are willing to prescribe exercise as a therapy for diabetic patients. In addition, there is a lack of information on how to(More)
BACKGROUND AND AIMS Apart from late motor nerve dysfunction, factors affecting muscle strength in diabetes are largely unknown. This study was aimed at assessing muscle strength correlates in diabetic subjects encompassing a wide range of peripheral nerve function and various degrees of micro and macrovascular complications. METHODS AND RESULTS(More)
PURPOSE The purpose of the present investigation was to determine whether short-term creatine (Cr) supplementation would affect 1) muscle contractile properties assessed by evoked and voluntary contractions, 2) force-velocity relationship, and 3) mean muscle fiber conduction velocity (CV). METHODS Using a double-blind random design, 16 moderately trained(More)