Massimiliano Sacco

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BACKGROUND Although periprosthetic bone loss remains a major concern in total hip arthroplasty, radiographic assessment of such loss is both difficult and subjective. In the present study, we assessed the ability of orthopaedic surgeons to reproducibly recognize changes in periprosthetic bone density on radiographs. We hypothesized that assessment of(More)
Seven cases of symptomatic non-parasitic congenital cysts of the liver are reported. Preoperative correct diagnosis can be established with non-invasive examinations, essentially with echotomography. Laparoscopy can represent a decisive investigation, permitting the direct view of the cysts. Surgical treatment of non-parasitic congenital cysts is based upon(More)
The current study examined the relationships among femoral stiffness, implant stiffness, and bone remodeling in 40 femurs retrieved at autopsy from 20 patients with unilateral uncemented hip replacements. The purpose of the study was to determine if the magnitude of periprosthetic bone loss after arthroplasty was correlated with, and could be predicted(More)
Blood transfusion and iron chelation currently represent a supportive therapy to manage anemia, vasculopathy and vaso-occlusion crises in Sickle-Cell-Disease. Here we describe the first 5-year long-term randomized clinical trial comparing Deferiprone versus Deferoxamine in patients with Sickle-Cell-Disease. The results of this study show that Deferiprone(More)
In patients with thalassemia intermedia (TI), such as beta-TI, alpha-thalassemia (mainly HbH disease and mild/moderate forms of HbE/beta-thalassemia), iron overload is an important challenge in terms of diagnosis, monitoring, and treatment. Moreover, to date, the only possible chelators available are deferoxamine, deferasirox, and deferiprone. Here, we(More)
On the basis of their own experience, totaling 540 examinations, the authors explain the advantages offered by the medium-length (100 cm) optical fibroscope in the diagnosis of colonic diseases. They claim that the instrument under discussion is the most complete, being at once sturdy and easy to use and affording, despite its limite length, exploration of(More)
Phenotypic improvement of hemoglobinopathies such as sickle cell disease and β-thalassemia (β-thal) has been shown in patients with high levels of Hb F. Among the drugs proposed to increase Hb F production, hydroxyurea (HU) is currently the only one proven to improve the clinical course of these diseases. However, Hb F increase and patient's response are(More)
BACKGROUND Real-life data on the use of R2 MRI for the assessment of liver iron concentration (LIC) remain limited. METHODS We conducted a cross-sectional analysis on 363 patients (mean age 35.6 yr, 44.1% men) with hemoglobinopathies (204 β-thalassemia major [TM], 102 β-thalassemia intermedia [TI], and 57 sickle cell disease [SCD]) that were evaluated(More)