Massimiliano Biagini

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We propose an experimental strategy for highly accurate selection of candidates for bacterial vaccines without using in vitro and/or in vivo protection assays. Starting from the observation that efficacious vaccines are constituted by conserved, surface-associated and/or secreted components, the strategy contemplates the parallel application of three high(More)
Streptococcus pneumoniae, like many other Gram-positive bacteria, assembles long filamentous pili on their surface through which they adhere to host cells. Pneumococcal pili are formed by a backbone, consisting of the repetition of the major component RrgB, and two accessory proteins (RrgA and RrgC). Here we reconstruct by transmission electron microscopy(More)
Clostridium difficile is a major cause of infectious diarrhea worldwide. Although the cell surface proteins are recognized to be important in clostridial pathogenesis, biological functions of only a few are known. Also, apart from the toxins, proteins exported by C. difficile into the extracellular milieu have been poorly studied. In order to identify novel(More)
Streptococcus agalactiae, also referred to as Group B Streptococcus (GBS), is one of the most common causes of life-threatening bacterial infections in infants. In recent years cell surface pili have been identified in several Gram-positive bacteria, including GBS, as important virulence factors and promising vaccine candidates. In GBS, three structurally(More)
Staphylococcus aureus is an opportunistic pathogen, commensal of the human skin and nares, but also responsible for invasive nosocomial as well as community acquired infections. Staphylococcus aureus adheres to the host tissues by means of surface adhesins, such as SdrC, SdrD, and SdrE proteins. The Sdr family of proteins together with a functional A(More)
The definition of LTE and LTE-Advanced standards aims at improving the performance of cellular networks with the final goal of a fair competition between wired and wireless communication systems. In order to guarantee excellent performance, one of the crucial challenge to cope with is the introduction of advanced channel estimation techniques for Multiple(More)
Among the several toxins used by pathogenic bacteria to target eukaryotic host cells, proteins that exert ADP-ribosylation activity represent a large and studied family of dangerous and potentially lethal toxins. These proteins alter cell physiology catalyzing the transfer of the ADP-ribose unit from NAD to cellular proteins involved in key metabolic(More)
Active noise control (ANC) techniques have been intensively studied and applied for the cancellation of stationary noise. More recently, adaptive solutions for the case of impulsive noise, i.e. stochastic processes for which statistical moments superior to the first are not defined, have been proposed in the literature. Nevertheless, such a model fits a(More)
Orthogonal Frequency Division Multiplexing (OFDM) transmission technique has been considered for the 4G LTE-Advanced system because of its high performance and low complexity. In the new 5G scenario this type of modulation is not properly suited because of the additional requirements for very high spectral efficiency, low latency and low out-of-band (OOB)(More)