Masoud Najafi

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BACKGROUND Oxidative stress plays an important role in the pathogenesis and progression of γ-irradiation-induced cellular damage, Lung is a radiosensitive organ and its damage is a dose-limiting factor in radiotherapy. The administration of dietary antioxidants has been suggested to protect against the succeeding tissue damage. The present study aimed to(More)
OBJECTIVE The out-of-field/non-target effect is one of the most important phenomena of ionizing radiation that leads to molecular and cellular damage to distant non-irradiated tissues. The most important concern about this phenomenon is carcinogenesis many years after radiation treatment. In vivo mechanisms and consequences of this phenomenon are not known(More)
This study was carried out to evaluate radioprotective effects of hesperidin (HES) administration before the irradiation on the cardiac oxidative stress and histopathological changes in an experimental rat model. The cardiovascular complications of radiation exposure cause morbidity and mortality in patients who received radiotherapy. HES, an antioxidant(More)
Scicos is a software environment for modeling and simulation of dynamical systems. The underlying formalism in Scicos allows for modeling very general dynami-cal systems: systems including continuous, discrete and event based behaviors. This paper presents some aspects of the simulation software, especially the features which have to do with the hybrid(More)
The radiation-induced bystander effect is the phenomenon which non-irradiated cells exhibit effects along with their different levels as a result of signals received from nearby irradiated cells. Responses of non-irradiated cells may include changes in process of translation, gene expression, cell proliferation, apoptosis and cells death. These changes are(More)
Hybrid automaton is a standard model for describing a hybrid system. A hybrid automaton is a state machine augmented with differential equations and is generally represented by a graph composed of vertices and edges where vertices represent continuous activities and edges represent discrete transitions. Modeling a hybrid automaton with large number of(More)
Radiotherapy is one of the most relevant treatment options for cancer therapy with or without other treatment modalities including immunotherapy, surgery and chemotherapy. Exposure to heavy doses of ionizing radiation during radiotherapy results in short and long term side effects. It appears that many of these side effects are linked to inflammatory(More)
EO 2008 OLT Copyright The publishers will keep this document online on the Internet – or its possible replacement – starting from the date of publication barring exceptional circumstances. The online availability of the document implies permanent permission for anyone to read, to download, or to print out single copies for his/her own use and to use it(More)