Masoud Keighobadi

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Leishmaniasis is a protozoan infectious disease widely distributed all around the world. First line drugs including antimoniales are insufficient due to resistance in endemic areas and high toxicity. Azole antifungals like ketoconazole (KCZ) are also used as antileishmanial agents for several decades. In the present study, we evaluated in vitro(More)
OBJECTIVE To investigate the prevalence of depression in women with breast cancer and relate it to their health-related quality of life. METHODS The cross-sectional study was conducted at the Imam Khomeini Hospital in Iran between January and December 2009, and comprised 60 women with breast cancer with a mean age of 43.8 +/- 47.12 years. In order to(More)
Pedicolosis is one of the extrinsic epidemic and parasitic diseases in humans; where seen as head, body and pubes louse in affected patients. This accounts for as important complication especially in the societies with reduced health principles. The most important way for transferring this disease is by contacting with clothes, personal effects, bed or(More)
OBJECTIVE To evaluate the effect of doxorubicin and its pegylated liposomal formulation (Doxil, Caelyx) on in vitro susceptibility of promastigote and amastigote stages of Leishmania major. METHODS Throughout in vitro assays the IC50 was calculated in the promastigotes and amastigotes forms in J774 macrophage cell line. Also as cytotoxicity in J774 cell(More)
The azole antifungal drugs are an important class of chemotherapeutic agents with broad-spectrum of activity against yeasts and filamentous fungi, act in the ergosterol biosynthetic pathway through inhibition of the cytochrome P450-dependent enzyme sterol 14α-demethylase. Azole antifungals have also been repurposed for treatment of tropical protozoan(More)
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