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Early B-cell factors 2 and 3 (EBF2/3) regulate early migration of Cajal–Retzius cells from the cortical hem
Cajal–Retzius (CR) cells play a crucial role in the formation of the cerebral cortex, yet the molecules that control their development are largely unknown. Here, we show that Ebf transcriptionExpand
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Pharmacotherapy of cerebral ischemia
Background: Ischemic stroke remains one of the leading causes of death and disability in the developed world. Despite many promising preclinical results, the only pharmacologic treatments provenExpand
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Disrupted Slit-Robo signalling results in membranous ventricular septum defects and bicuspid aortic valves
Aims The mesenchymal cushions lining the early embryonic heart undergo complex remodelling to form the membranous ventricular septum as well as the atrioventricular and semilunar valves in laterExpand
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Robo1 Modulates Proliferation and Neurogenesis in the Developing Neocortex
The elaborate cytoarchitecture of the mammalian neocortex requires the timely production of its constituent pyramidal neurons and interneurons and their disposition in appropriate layers. NumerousExpand
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Isoflurane preconditioning affords functional neuroprotection in a murine model of intracerebral hemorrhage.
INTRODUCTION Exposure to isoflurane gas prior to neurological injury, known as anesthetic preconditioning, has been shown to provide neuroprotective benefits in animal models of ischemic stroke.Expand
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Slit–Roundabout Signaling Regulates the Development of the Cardiac Systemic Venous Return and Pericardium
Rationale: The Slit–Roundabout (Robo) signaling pathway has pleiotropic functions during Drosophila heart development. However, its role in mammalian heart development is largely unknown. Objective:Expand
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Nerve Growth Factor in the Hippocamposeptal System: Evidence for Activity-Dependent Anterograde Delivery and Modulation of Synaptic Activity
Neurotrophins have been implicated in regulating neuronal differentiation, promoting neuronal survival, and modulating synaptic efficacy and plasticity. The prevailing view is that, depending on theExpand
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