Masha V Poyurovsky

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OBJECTIVE Rho-associated kinase (ROCK) is a key regulator of numerous processes in multiple cell types relevant in stroke pathophysiology. ROCK inhibitors have improved outcome in experimental models of acute ischemic or hemorrhagic stroke. However, the relevant ROCK isoform (ROCK1 or ROCK2) in acute stroke is not known. METHODS We characterized the(More)
Mdm2 also has auto-ubiquitination activity, whereby it can regulate itself via protein degradation (9). In addition, a tran-scriptional target of p53 is the Mdm2 gene, creating an auto-regulatory negative feedback loop between Mdm2 and p53 (10). Once a stress response is removed or resolved, p53 returns to basal levels due to Mdm2-mediated degradation and(More)
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