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We propose a novel approach of knowledge visualization technique by generating knowledge through a graph-based clustering technique, incorporating tacit knowledge and finally visualizing the knowledge in dashboard form. Three aspects are emphasized: clustering technique, knowledge visualization and domain knowledge interaction. Clustering technique with the(More)
AIM To study the effects of matrine (Mat) on lipopolysaccharides (LPS)-induced fatal hepatitis in D-galactosamine (D-GalN)-sensitized mice and tumor necrosis factor (TNF) release from peritoneal macrophages (PMO). METHODS Mice were pretreated with Mat (10, 50 mg.kg-1, i.p., bid x 3 d), and then injected i.p. LPS + D-GalN. Liver injury was assessed by(More)
The effects of CCK-8 on the mean arterial pressure (MAP), blood components and path-morphological changes during endotoxin shock (endotoxin, 8 mg/kg b.w.iv.) in rats, as well as on the 24 h mortality rate (MR) of the lead-sensitized rats in endotoxin shock (endotoxin 1 microgram/100 g b.w.iv.) were observed. The results showed that injection of CCK in ES(More)
The effect of matrine (Mat) on lipopolysaccharides (LPS)-induced fatal hepatitis and tumor necrosis factor (TNF) production in Propionibacterium acnes (PA)-primed mice were studied. Mice were injected i.p. LPS (10 micrograms/mouse) 7 d after i.p. PA (0.5 ml/mouse) to induce fatal hepatitis. After i.p. LPS, serum TNF activity rose to 1657 +/- 406 kU.L-1 at(More)
OBJECTIVE To study the value of 3D reconstructive technique in midfacial fractures,especially its significance in preoperative diagnosis and operation planning of complicated,multiple fractures in midface. METHODS To preoperatively scan and reconstruct 47 fracture patients with spiral CT. RESULTS 38 cases received operation which confirmed the(More)
OBJECTIVE To detect the location of inducible nitric oxide synthetase (iNOS) protein and mRNA in lung during endotoxemia in rabbits. METHODS Northern blotting was performed before, 1 hour and 5 hours after the intravenous administration of lipopolysaccharide (LPS) in rabbits. Immunohistochemical analysis (IA), in situ hybridization and in situ reverse(More)
Changes in mean artery pressure (MAP), pulmonary artery pressure (PAP) and nitric oxide (NO) contents in inflow and outflow pulmonary blood(IPB,OPB) were observed after endotoxin lipopolysacchride (LPS) was injected i.v. in rabbits. Changes of PAP and lung injury were also observed after inhibitor of NO synthesis L-NNA or inhibitor of inducible NO synthesis(More)
Porphyromonas gingivalis, an important periodontal pathogen, has been proved to actively invade cells, induce endothelial cell activation, and promote development of atherosclerosis. Innate immune surveillance, which includes the activity of nucleotide-binding oligomerization domain (NOD)-like receptors (NLRs) and Toll-like receptors (TLRs), are essential(More)
Several parts of Alternanthera philoxeroides were extracted by lead-salt sedimentation and double phase solvent extractive technique and their antiviral effects were studied. The results showed that extracts of petroleum ether, ether, and ethyl acetate have inhibitory effect on epidemic hemorrhagic fever virus (EHFV). The antiviral effective part is(More)