Masayuki Makino

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Toxoplasma gondii-derived heat shock protein 70 (T.g.HSP70) is a tachyzoite-specific virulent molecule expressed before the death of hosts. We have already demonstrated the vaccine effects of T.g.HSP70 gene targeting peripheral epidermal or dermal dendritic cells (DC) to limit T. gondii loads in T. gondii-infected mice. In the present study, involvement of(More)
Toxoplasma gondii-derived heat shock protein 70 (T.g.HSP70) was proven to induce lethal anaphylactic reaction in T. gondii-infected mice through platelet-activating factor (PAF)-mediated, but not classical IgE-dependent, pathway via TLR4/MyD88 signal pathway. The effector cells generating PAF and causing T.g.HSP70-induced anaphylactic reaction were CD11b(+)(More)
A method of generating alternative/exceptional scenarios using differential information is presented. Behaviors of normal scenarios of similar purpose are quite similar, while actors and data in scenarios are different among these scenarios. We derive the differential information between them and apply the information to generate new alternative/exceptional(More)
In this paper an effort is made to design a stable and energy efficient asymmetrical 6T SRAM cell in 65nm technology generation with one bit line for read and one for write operation along with dual word lines. A simple energy recovery driver is added to enhance the write ability of the SRAM and to recover energy. Sizing the access transistor helps write(More)
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