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Both isoforms of human UDP-glucose:glycoprotein glucosyltransferase are enzymatically active.
Being recognized as an important constituent of the glycoprotein folding cycle, uridine diphosphate-glucose:glycoprotein glucosyltransferase (UGGT) has been a subject of intense study. Up to now, it… Expand
Functional analysis of endoplasmic reticulum glucosyltransferase (UGGT): Synthetic chemistry's initiative in glycobiology.
- Y. Ito, Y. Takeda, A. Seko, Masayuki Izumi, Y. Kajihara
- Medicine, Biology
- Seminars in cell & developmental biology
- 1 May 2015
UGGT1 is called as a folding sensor protein that recognizes misfolded glycoproteins and selectively glucosylates high-mannose-type glycans on the proteins. However, conventional approaches using… Expand
Chemical synthesis of an erythropoietin glycoform containing a complex-type disialyloligosaccharide.
Association of Oral Fat Sensitivity with Body Mass Index, Taste Preference, and Eating Habits in Healthy Japanese Young Adults.
- Masanobu Asano, Guang Hong, +5 authors T. Kudo
- The Tohoku journal of experimental medicine
- 1 February 2016
Oral fat sensitivity (OFS, the ability to detect fat) may be related to overeating-induced obesity. However, it is largely unknown whether OFS affects taste preference and eating habits. Therefore,… Expand
Polyamine Concentrations in the Brain of Vitamin B12-Deficient Rats
- K. Adachi, Masayuki Izumi, +4 authors T. Mitsuma
- Biology, Medicine
- Experimental biology and medicine
- 1 October 2003
To study the pathophysiology of the neuronal degeneration in vitamin B12 deficiency, we investigated the concentrations of the polyamines putrescine, spermidine, and spermine in brain regions and… Expand
Efficient and stereoselective 1,2-cis glycoside formation of 5-thioaldopyranoses: glycosylation with peracetylated 5-thio-D- arabinopyranosyl and 5-thio-L-fucopyranosyl trichloroacetimidates
Abstract Trichloroacetimidate method was proved to be effective for 5-thio- D -arabinopyranosylation and 5-thio- L -fucopyranosylation of N -acetyl- D -glucosaminides and D -galactosides. In these… Expand
Decoration of proteins with sugar chains: recent advances in glycoprotein synthesis.
- R. Okamoto, Masayuki Izumi, Y. Kajihara
- Medicine, Chemistry
- Current opinion in chemical biology
- 1 October 2014
Chemical or chemoenzymatic synthesis is an emerging approach to produce homogeneous glycoproteins, which are hard to obtain by conventional biotechnology methods. Recent advances in the synthetic… Expand
Expression of α2,8/2,9-Polysialyltransferase fromEscherichia coli K92
- Gwo-Jenn Shen, A. Datta, Masayuki Izumi, K. M. Koeller, C. Wong
- The Journal of Biological Chemistry
- 3 December 1999
The capsular polysaccharide of Escherichia coli K92 contains alternating -8-NeuAcα2- and -9-NeuAcα2- linkages. The enzyme catalyzing this polymerizing reaction has been cloned from the genomic DNA of… Expand
Synthesis of 5‐Thio‐L‐fucose‐Containing Disaccharides, as Sequence‐ Specific Inhibitors, and 2′‐Fucosyllactose, as a Substrate of α‐ L‐Fucosidases.
Monitoring of Glycoprotein Quality Control System with a Series of Chemically Synthesized Homogeneous Native and Misfolded Glycoproteins.
- Tatsuto Kiuchi, Masayuki Izumi, +7 authors Y. Kajihara
- Medicine, Chemistry
- Journal of the American Chemical Society
- 26 November 2018
The glycoprotein quality control (GQC) system in the endoplasmic reticulum (ER) effectively uses chaperone-type enzymes and lectins such as UDP-glucose:glycoprotein glucosyltransferase (UGGT),… Expand