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An open-label randomised comparison of efficacy and tolerability of irinotecan plus high-dose 5-fluorouracil (5-FU) and leucovorin (LV) (ILF) with etoposide plus 5-FU/LV (ELF) in patients with untreated metastatic or locally advanced gastric cancer. One cycle of ILF comprised six once-weekly infusions of irinotecan 80 mg m(-2), LV 500 mg m(-2), 24-h 5-FU(More)
Survival of the rabbit retinal pigment epithelium (RPE) after ischemia was studied. The ischemia was induced by elevating intraocular pressure; retinal and RPE function were monitored by electrophysiologic recordings. The b-wave recovered to control amplitude in 1-4 hr after 30-60 min of ischemia, but it never recovered more than about 50% amplitude after(More)
The heat shock proteins gp96, HSP70, and HSP90 are complexed to a diverse array of cellular proteins and peptides as a consequence of their chaperone functions. There is good experimental evidence that vaccination with these heat shock protein-peptide complexes elicit immune responses against chaperoned peptide antigens. As shown with gp96, this requires(More)
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