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  • Masayuki Hatanaka, Bernhard Maier, +4 authors Raghavendra G Mirmira
  • Biology, Medicine
  • Diabetes
  • 2014 (First Published: 1 October 2014)
  • Saturated free fatty acids (FFAs) have complex effects on the islet β-cell, acutely promoting adaptive hyperplasia but chronically impairing insulin release. The acute effects of FFAs remainContinue Reading
  • Masayuki Hatanaka, Katsuya Tanabe, +6 authors Yukio Tanizawa
  • Biology, Medicine
  • Human molecular genetics
  • 2011 (First Published: 1 April 2011)
  • Wolfram syndrome is an autosomal recessive disorder characterized by juvenile-onset insulin-dependent diabetes mellitus and optic atrophy. The gene responsible for the syndrome (WFS1) encodes anContinue Reading
  • Emily K Sims, Masayuki Hatanaka, +8 authors Carmella Evans-Molina
  • Biology, Medicine
  • American journal of physiology. Endocrinology and…
  • 2013 (First Published: 15 December 2013)
  • Impaired glucose tolerance (IGT) and type 2 diabetes (T2DM) are polygenic disorders with complex pathophysiologies; recapitulating them with mouse models is challenging. Despite 70% genetic homology,Continue Reading
  • Masayuki Hatanaka, Emily K. Anderson-Baucum, +7 authors Emily K Sims
  • Biology, Chemistry, Medicine
  • Scientific Reports
  • 2017 (First Published: 19 June 2017)
  • Under conditions of high fat diet (HFD) consumption, glucose dyshomeostasis develops when β-cells are unable to adapt to peripheral insulin demands. Few studies have interrogated the molecularContinue Reading
  • Yurika Nishiki, Adeola F. Adewola, Masayuki Hatanaka, Andrew T Templin, Bernhard Dipl.-Ing. Maier, Raghavendra G Mirmira
  • Biology, Medicine
  • Molecular endocrinology
  • 2013 (First Published: 1 February 2013)
  • The MAPKs are transducers of extracellular signals such as proinflammatory cytokines. In islet β-cells, cytokines acutely activate expression of the Nos2 gene encoding inducible nitric oxide synthaseContinue Reading