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  • Masaya Hirose, Toshimasa Ishizaki, +7 authors Shuh Narumiya
  • Biology, Medicine
  • The Journal of cell biology
  • 1998 (First Publication: 29 June 1998)
  • A critical role for the small GTPase Rho and one of its targets, p160ROCK (a Rho-associated coiled coil-forming protein kinase), in neurite remodeling was examined in neuroblastoma N1E-115 cells.Continue Reading
  • Kazuyuki Itoh, Kiyoko Yoshioka, Hitoshi Akedo, Masayoshi Uehata, Toshimasa Ishizaki, Shuh Narumiya
  • Medicine, Biology
  • Nature Medicine
  • 1999 (First Publication: 1 February 1999)
  • Adhesion of tumor cells to host cell layers and subsequent transcellular migration are pivotal steps in cancer invasion and metastasis. The small GTPase Rho controls cell adhesion and motilityContinue Reading
  • Hideki Tokushige, Masaru Inatani, +4 authors Hidenobu Tanihara
  • Biology, Medicine
  • Investigative ophthalmology & visual science
  • 2007 (First Publication: 1 July 2007)
  • PURPOSE To elucidate the intraocular pressure (IOP)-lowering effects and associated characteristics of Y-39983, a selective Rho-associated coiled coil-forming protein kinase (ROCK) inhibitor derivedContinue Reading
  • Takashi Ono, Takahiro Miyazaki, Yoshihito Ishida, Masayoshi Uehata, Kazuhiro Nagata
  • Biology, Medicine
  • The Journal of biological chemistry
  • 2012 (First Publication: 24 February 2012)
  • Hsp47 (heat shock protein 47), a collagen-specific molecular chaperone, is essential for the maturation of various types of procollagens. Previous studies have suggested that Hsp47 may preferentiallyContinue Reading