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We retrospectively investigated the effects of adding glimepiride in patients with type 2 diabetes showing suboptimal control by insulin therapy. Of 63 patients with poorly controlled insulin-treated type 2 diabetes (baseline HbA1c, 8.4 +/- 0.6%), 32 were treated with insulin alone and 31 were given glimepiride in addition to insulin. HbA1c values, daily(More)
The oxidation of the pyrazolate bridged cyclic PtII trimer, [Pt3(mu-pz)6] (1), in the presence of bromide ion gave a deep blue mixed-valent Pt(II,III,III) complex, [Pt3Br2(mu-pz)6] (2). The structural analysis of 2 disclosed that the complex has localized Pt--Pt bond. Our theoretical calculations revealed that the HOMO and LUMO of Pt3 (II,III,III) species(More)
The discovery of polypyrazolylborate ligands allowed the development of various chemical fields and these ligands are an alternative to cyclopentadienyl, because both ligands have the same charge and donate the same number of electrons, as well as adopting the same facial geometry. Easy control of the bulkiness of polypyrazolylborate ligands is possible by(More)
Hydration of nitrosylruthenium bis(alkynyl) complex TpRu(CCPh)2(NO) (1) (Tp = BH(pyrazol-1-yl)3) was carried out in the presence of HBF4.Et2O in distilled MeOH and afforded the metallacycle TpRu{CH=C(Ph)C(O)CH(Ph)}(NO) (2) (39%) and the bis(ketonyl) TpRu(CH2C(O)Ph)2(NO) (3) (37%). While double hydration of 1 gave 3, 2 was produced through a combination of(More)
The hydroxido-bridged dinuclear ruthenium complex 4, which is supported by Tp ligands, has been prepared from protonation of the oxido-bridged dinuclear ruthenium complex 3. Additional protonation of 4, affording the aqua-bridged dinuclear ruthenium complex 5 in situ, and subsequent treatment with NO gave rise to the dicationic dinitrosyl complex 2. These(More)
The N-C coupling of ligating NO with 2-vinylpyridines, affording nitrosovinyl complexes, was found. This is of significance since the reaction process involves a C-H activation of the vinyl moiety and subsequent C-N bond formation. Furthermore, we show that the resulting nitrosovinyl complexes are chemically versatile and potentially valuable species.(More)
The platinum dimer and heteropolynuclear platinum complexes of 3,5-dimethylpyrazolate, [Pt2M4(mu-Me2pz)8] [M = H (1), Ag (2), Cu (3)], were synthesized and structurally characterized. They exhibit yellow, sky-blue, and orange luminescence, respectively, in the solid state. The absorption bands of 2 and 3 are mainly assigned to the combination of the(More)
A nitrosylruthenium alkynyl complex of TpRuCl(C[triple bond]CPh)(NO)(1a) was reacted with PPh3 in the presence of HBF4.Et2O at room temperature to give a beta-phosphonio-alkenyl complex (E)-[TpRuCl{CH=C(PPh3)Ph}(NO)]BF4(2.BF4). On the other hand, for gamma-hydroxyalkynyl complexes TpRuCl{C[triple bond]CC(R)2OH}(NO)(R = Me (1b), Ph (1c), H (1d)), similar(More)