Masayoshi Miyamoto

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We present the core graphics technologies used to render and light the world of <i>Final Fantasy XV</i>. The latest iteration of the franchise displays a seamless environment more dynamic than ever before, with special features such as dynamic weather, time of day, and procedural sky and clouds. We first describe the hybrid global illumination system based(More)
Cytochrome P450 reductase (CPR) is an important redox partner of microsomal CYPs. CPR is composed of a membrane anchor and a catalytic domain that contains FAD and flavin mononucleotide (FMN) as redox centers and mediates electron transfer to CYP. Although the CPR membrane anchor is believed to be requisite for interaction with CYP, its physiological role(More)
The investigation of cytochrome P450 (CYP) mediated metabolism reactions by determination of enzyme kinetic parameters, Michaelis constant (K(m)), maximum reaction velocity (V(max)), and intrinsic clearance (CL(int)) is important aspects in discovery and development of drugs. The kinetic parameters can be used to predict the clearance prior to human(More)
In FINAL FANTASY XV, a triple-A open world RPG, we have proposed a new method of smart gameplay sharing by introducing a novel mechanism of automatic gameplay photograph generation. Unlike the classic screenshots that most players are familiar with, the photographs generated are depicted as though they were seen from the perspective of the in-game AI(More)
Although cytochromes P450 2C9 (CYP2C9) and 2C19 (CYP2C19) have 91% amino acid identity, they have different substrate specificities. Previous studies have suggested that several amino acid residues may be involved in substrate specificity. In this study, we focused on the roles of two amino acids, residues 72 and 241. The amino acids in these positions have(More)
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