Masayoshi Iizuka

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The origin recognition complex (ORC) is an initiator protein for DNA replication, but also effects transcrip-tional silencing in Saccharomyces cerevisiae and hetero-chromatin function in Drosophila. It is not known, however , whether any of these functions of ORC is conserved in mammals. We report the identification of a novel protein, HBO1 (histone(More)
The ectopic expression of the glucose-dependent insulinotropic polypeptide receptor (GIPR) in the human adrenal gland causes significant hypercortisolemia after ingestion of each meal and leads to Cushing's syndrome, implying that human GIPR activation is capable of robustly activating adrenal glucocorticoid secretion. In this study, we transiently(More)
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