Masayo Fujimoto

Learn More
Epigenetic alterations in cancer, especially DNA methylation and histone modification, exert a significant effect on the deregulated expression of cancer-related genes and lay an epigenetic pathway to carcinogenesis and tumor progression. Global hypomethylation and local hypermethylation of CpG islands in the promoter region, which result in silencing tumor(More)
This study found that the use of a computer conferencing system in an R&D lab was significantly shaped by a set of intervening actors—mediators—who actively guided and manipulated the technology and its use over time. These mediators adapted the technology to its initial context and shaped user interaction with it; over time, they continued(More)
Nerve growth factor and its high-affinity receptor TrkA are thought to be involved in the progression of various cancers. This study investigated the mechanism that regulates aberrant or increased TrkA expression in various cancer cell lines and in the course of pancreatic cancer progression. We found that the negative cis-acting AP-1-like sequence TGAGCGA(More)
This paper reports on a study into the administrative activities surrounding a computer conferencing system used by a product development group within a large Japanese manufacturing firm. Drawing on interview and textual data, the study investigated the goals, deliberations, responsibilities, and outcomes of administrators of the group's conferencing(More)
Increasing usage of ICT in medical organizations raises the issue of information security. This research study focuses on, and analyzes technology and management aspects for, information security of networked medical organizations through a teleradiology case study. A 'workshop' to gauge risk assessment was also established in which stakeholders, such as(More)
Mitochondrial diabetes is characterized by diabetes and hearing loss in maternal transmission with a heteroplasmic A3243G mutation in the mitochondrial gene. In patients with the mutation, it has been reported that hepatic involvement is rarely observed. We demonstrated a case of hypertrophic cardiomyopathy and hepatic failure with mitochondrial diabetes.(More)
We suggest that a mechanism for facilitating the context-specificity of technologies in use already exists in organizations, but is under-appreciated, under-utilized, and under-managed. We studied the use of a conferencing technology and found that its effectiveness was significantly shaped by a set of actors-technology mediators-who actively guided and(More)
  • 1