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The localization of glucocorticoid receptor (GR) immunoreactivity and mRNA in the adult rat brain was examined by light microscopic and electron microscopic immunohistochemistries, and in situ hybridization. For the purpose of detailed investigation of the distribution and comparison of GR immunoreactivities and mRNAs, specific polyclonal antibodies against(More)
To study the projection from the pretectum to the dorsal lateral geniculate nucleus (LGNd) in the cat, we used anterograde and retrograde transport of wheat germ agglutinin-horseradish peroxidase (WGA-HRP). Special attention was directed to the retinotopic maps of the pretectum and LGNd. Multiple restricted injections were made into different parts of the(More)
We observed morphological subtypes of visual pretectal neurons ascending to the dorsal thalamus, following injections of wheat germ agglutinin conjugated to horseradish peroxidase into the dorsal lateral geniculate nucleus (LGNd) or the pulvinar nucleus. These neurons are composed of fusiform cells and small-sized multipolar cells in the olivary pretectal(More)
To examine the effect of short-term and long-term adrenalectomy (ADX) on the glucocorticoid receptor (GR) expression, we performed an immunohistochemical study on the rat forebrain. One day after ADX, the GR-immunoreactivity significantly decreased or disappeared in most forebrain structures, while relatively strong GR-immunoreactivity was still found(More)
In the negative feedback model, loss of endogenous glucocorticoids up-regulates the expression of glucocorticoid receptor mRNA. To elucidate further the effect of chronic lack of glucocorticoids on the expression of glucocorticoid receptor mRNA and protein, in situ hybridization and immunohistochemical methods were used to examine the long-term alteration(More)
Macro-electrophoretic applications of the cellular neurotoxin ibotenic acid into the ventromedial hypothalamic nucleus (VMH) resulted in hyperphagia and obesity in male rats. Histological examination showed a reduction in the number of neuronal VMH cell bodies with glial proliferation without evidence of non-specific damage. This supports the hypothesis(More)
Glucocorticoids exert various neuroendocrinological effects, including stress response, in the central nervous system via glucocorticoid receptor (GR). GRs are transported from the cytoplasm to the nucleus upon ligand binding, and then exert the transcriptional activity. Although it is important for unraveling the actual property of the GR in vivo,(More)
We investigated the effects of nerve growth factor (NGF) and glucocorticoid on the differentiation of rat chromaffin cells during development (postnatal day 0, 5, 10, 15, 25) in vitro, by evaluating four parameters of cytological alterations; the percentage of process-bearing cells, the number of primary processes, the number of branches per cell and the(More)
High angular resolution images of extragalactic radio sources are being made with the Highly Advanced Laboratory for Communications and Astronomy (HALCA) satellite and ground-based radio telescopes as part of the Very Long Baseline Interferometry (VLBI) Space Observatory Programme (VSOP). VSOP observations at 1.6 and 5 gigahertz of the(More)
An orbiting spacecraft and ground observatories have been used to obtain interferometric observations of cosmic radio sources. The Tracking and Data Relay Satellite System (TDRSS) was used as the orbiting observatory in conjunction with two 64- meter radio telescopes at ground observatories, one in Australia and one in Japan. The quasars 1730-130 (NRAO(More)