Masatoshi Niigaki

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Abdominal fat accumulation, which induces high intra-abdominal pressure that causes increase in the gastroesophageal pressure gradient and hiatal hernia, as well as obesity, has been shown to increase the prevalence of gastroesophageal reflux disease (GERD). This study was performed to clarify the association between metabolic syndrome and the prevalence of(More)
BACKGROUND AND AIM Rabeprazole has a faster onset of antisecretory activity than omeprazole and lansoprazole. The aim of the present study was to clarify whether there is any difference in the speed of symptom relief in patients with reflux esophagitis following the administration of these three proton pump inhibitors (PPI). METHODS Eighty-five patients(More)
It is unclear whether infection with hepatitis B virus (HBV) or hepatitis C virus (HCV) affects arteriosclerosis. We performed a cross-sectional study to clarify the effect of HBV and HCV infection on arteriosclerosis. The study subjects were 1806 healthy individuals who visited Shimane Environment and Health Public Corporation for routine medical(More)
To the Editor: Duodenal varices are rarely seen; however, in patients with portal hypertension, they may cause extensive and fatal gastrointestinal hemorrhaging. Here we describe a patient with bleeding duodenal varices who was successfully treated by endoscopic injection sclerotherapy (EIS) with α-cyanoacrylate (αCA) and absolute ethanol, followed by(More)
BACKGROUND The therapeutic effect of combined administration of prokinetics and histamine H2 receptor antagonists (H2RA) in gastroesophageal reflux disease is reported to be superior to that of monotherapy with H2RA alone. In addition to its acid-suppressing effect, the H2RA nizatidine also has a prokinetic action by suppressing acetylcholine esterase. The(More)
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