Masatoshi Matsuo

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Flutamide, which has antiandrogenic properties, was administered to pregnant rats, and effects on male offspring were examined. Crj: CD (SD) IGS (SPF) females were administered flutamide (0.15, 0.6, 2.5, 10.0, 100 mg/kg, p.o.) from gestation Day 14 to post parturition Day 3. The number of pups, body weights, clinical features, anogenital distance (AGD),(More)
As part of an international validation project to establish a test protocol for the 'Enhanced OECD Test Guideline no. 407', a 28-day repeated dose study of flutamide was performed (1) to examine which of the current and/or additional parameters can detect endocrine effects of test chemicals most reliably and sensitively, (2) to investigate whether it is(More)
A Software Designer's Associates (SDA) is, 1) a workstation-based, coherent, upgradable collection of tools, 2) capable of supporting the description, evaluation and comparison of software system architectural designs, and 3) molded to a specific user's habits, the tasks a designer is performing and the method a designer is using. Each SDA is a specific(More)
BACKGROUND The aim of the present study was to investigate the validity of the contactless vital sensing system that we previously developed. METHODS A total of 111 healthy Japanese subjects were recruited from the University of Occupational and Environmental Health and the Panasonic Corporation AVC Networks Company. All subjects underwent an evaluation(More)
There is evidence that radiation exposure is a causative factor of myelodysplastic syndromes (MDS). However, little is known about whether radiation exposure is also a prognostic factor of MDS. We investigated the impact of radiation exposure on the prognosis of MDS in Nagasaki atomic bomb survivors using the International Prognostic Scoring System (IPSS)(More)
Cerebral involvement frequently occurs in association with progression or relapse of malignant lymphoma. Chemotherapy with cyclophosphamide, doxorubicin, vincristine, and prednisolone, the standard chemotherapy for malignant lymphoma, is an ineffective treatment for cerebral involvement because these drugs cannot cross the blood-brain barrier. Therefore,(More)
A Software Designer's Associate (SDA) is a workstation-based collection of tools which support: 1) the description, evaluation and comparison of software system architectural designs, and 2) cooperation among, and management of, a team of software designers [Ridd87]. Each Software Designer's Associate is a specific instance of a generic facility which(More)
Pregnant rats were administered flutamide (0 and 10 mg/kg, p.o.) from gestation Day 14 to post-parturition Day 3 and effects on responsiveness to androgens (testosterone propionate, TP; dihydrotestosterone, DHT) in male offspring were examined with a Hershberger assay. Male pups of each group were assigned to 6 subgroups as follows: Group 1, castration and(More)
An appropriate trigger for BCR-ABL1 mutation analysis has not yet been established in unselected cohorts of chronic-phase chronic myelogenous leukemia patients. We examined 92 patients after 12 months of tyrosine kinase inhibitor (TKI) treatment in Nagasaki Prefecture, Japan. Univariate analysis revealed that significant factors associated with not(More)
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