Masato Yoshioka

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We isolated mouse cDNA encoding a novel FGF (251 amino acids). As this is the 23rd documented FGF, we termed it FGF-23. FGF-23 has a hydrophobic amino terminus ( approximately 24 amino acids), which is a typical signal sequence. As expected, recombinant mouse FGF-23 was efficiently secreted by High Five insect cell-infected recombinant baculovirus(More)
This 10-b 50-MSamples/s SAR analog-to-digital converter (ADC) features on-chip digital calibration techniques, comparator offset cancellation, a capacitor digital-to-analog converter (CDAC) linearity calibration, and internal clock control to compensate for PVT variations. A split-CDAC reduces the exponential increase in the number of unit capacitors needed(More)
OBJECTIVE To investigate the role of Nrf2 in the pathogenesis of hepatic ischemia-reperfusion (I/R) injury. BACKGROUND Hepatic I/R injury is a serious complication that leads to liver failure after liver surgery. NF-E2-related factor 2 (Nrf2) is a transcription factor that plays a critical role in protecting cells against oxidative stress. Therefore, it(More)
INTRODUCTION We introduce a technique for pancreaticojejunostomy with closure of the pancreatic stump by endoscopic linear stapler as a reliable intervention with benefits for pancreatic resection in laparoscopic pancreaticoduodenectomy (Lap-PD). MATERIALS AND SURGICAL TECHNIQUE Following laparoscopic resection, we perform pancreaticojejunostomy under(More)
BACKGROUND Whether hepatic resection is indicated for elderly patients with hepatocellular carcinoma (HCC) remains controversial. METHODS This retrospective study evaluated surgical outcomes and prognostic factors in elderly patients with HCC who underwent hepatectomy. Overall survival rates and disease-free survival rates after hepatectomy were compared(More)
BACKGROUND/AIM To preserve pancreatic function, segmental pancreatectomy has been proposed for benign or low-malignancy tumors in the pancreatic body. Indications for the procedure, however, are still controversial. METHODS In this study, we investigated the advantages and disadvantages of segmental pancreatectomy compared with distal pancreatectomy and(More)
We used positron emission tomography with 2-deoxy-2-[18F]fluoro-d-glucose (FDG-PET) in the diagnosis of two cases of malignant intraductal papillary mucinous tumor (IPMT) of the pancreas. A 56-year-old man and a 72-year-old man, both with tumors in the pancreatic head, were referred to Akita University Medical Center. Computed tomography revealed tumors(More)
A split capacitor DAC calibration method is proposed that a bridge capacitor larger than conventional design allows a tunable capacitor to compensate for mismatch. To guarantee proper calibration, a comparator with digital timing control offset cancellation is proposed. An 8-bit successive approximation ADC with 4b+4b split capacitor DAC calibration has(More)
Prostanoids play a pivotal role among the inflammatory mediators associated with I/R injury. The aim of this study was to determine the effects of oral supplementation of n-3 polyunsaturated fatty acids (PUFA)-rich oil on inflammatory reactions and microcirculatory disorders caused by a hepatic warm I/R in rats. The rats were orally supplemented with n-3(More)