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Design and synthesis of 3-substituted benzamide derivatives as Bcr-Abl kinase inhibitors.
A series of 3-substituted benzamide derivatives structurally related to STI-571 (imatinib mesylate), a Bcr-Abl tyrosine kinase inhibitor used to treat chronic myeloid leukemia (CML), was prepared andExpand
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Effects of serotonin-norepinephrine reuptake inhibitors on locomotion and prefrontal monoamine release in spontaneously hypertensive rats.
Catecholamine neurotransmission in the prefrontal cortex plays a key role in the therapeutic actions of drugs for attention-deficit/hyperactivity disorder (ADHD). Recent clinical studies show thatExpand
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Effects of acute and chronic administration of venlafaxine and desipramine on extracellular monoamine levels in the mouse prefrontal cortex and striatum.
Prefrontal catecholamine neurotransmission plays a key role in the therapeutic actions of drugs for attention-deficit/hyperactivity disorder (ADHD). We have recently shown thatExpand
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Atomoxetine-Induced Increases in Monoamine Release in the Prefrontal Cortex are Similar in Spontaneously Hypertensive Rats and Wistar-Kyoto Rats
Spontaneously hypertensive rats (SHRs) are used as a model for attention-deficit/hyperactivity disorder (ADHD), since SHRs are hyperactive and show defective sustained attention in behavioral tasks.Expand
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The analgesic effect of tramadol in animal models of neuropathic pain and fibromyalgia
(±)-Tramadol hydrochloride (tramadol) is a widely used analgesic for the treatment of cancer pain and chronic pain. Although many animal studies have shown antinociceptive effects of tramadol in bothExpand
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Methylphenidate and venlafaxine attenuate locomotion in spontaneously hypertensive rats, an animal model of attention–deficit/hyperactivity disorder, through &agr;2-adrenoceptor activation
Recent clinical studies have shown that serotonin–norepinephrine reuptake inhibitors such as venlafaxine and duloxetine are effective against symptoms of attention–deficit/hyperactivity disorder suchExpand
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Prospects for automotive SiP modules applying IC assembly and packaging technology
Abstract We develop a package that ensures quality complying with AEC-Q 100 Grade 2 which is in-vehicle quality from various flip chip mounting methods and bump sealing technology with underfill re...