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The epidermis shows a distinctive pattern of differentiation wherein keratinocytes proliferate in the basal cell layer and mature into spinous and granular cells. Using a discontinuous density-gradient centrifugation method, guinea-pig keratinocytes were separated into high (HDF), intermediate (IDF), and low (LDF) density fractions. Morphological and flow(More)
How long did it take to traverse the eighteenth-century Atlantic? The answer was often a matter of guesswork, for whilst the distance could be calculated, the duration could not. Even allowing for piracy, inclement weather, or navigational error, a voyage might last three weeks or two months. Ships carrying time-sensitive materials such as newspapers,(More)
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