Masato Chiba

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1Hiroshi Mizuuchi
1Tetsuya Mitsudomi
1Kazuko Sakai
1Takehiro Fukami
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Mutant selective epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs), such as rociletinib and AZD9291, are effective for tumors with T790M secondary mutation that become refractory to first-generation EGFR-TKI. However, acquired resistance to these prospective drugs is anticipated considering the high adaptability of cancer cells and the(More)
A series of trans-3-oxospiro[(aza)isobenzofuran-1(3H),1'-cyclohexane]-4'-carboxamide derivatives were synthesized and profiled for NPY Y5 binding affinity, brain and CSF penetrability in rats, and susceptibility to human and mouse P-glycoprotein transporters in order to develop a PET ligand. Compound 12b exhibited an acceptable profile for a PET ligand, and(More)
Research and development of public data networks have been conducted by various countries to cope with recent diverse data communication demands. Nippon Telegraph and Telephone Public Corporation (NTT) has also been advancing developmental projects on a packet switched network and a circuit switched network. Commercial tests on each will be begun in 1979. (More)
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