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PURPOSE To assess the pharmacology of perampanel and its antiseizure activity in preclinical models. Perampanel [2-(2-oxo-1-phenyl-5-pyridin-2-yl-1,2-dihydropyridin-3-yl) benzonitrile] is a novel, orally active, prospective antiepileptic agent currently in development for refractory partial-onset seizures. METHODS Perampanel pharmacology was assessed by(More)
Amelioration of experimental autoimmune encephalomyelitis (EAE) by blockade of the alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate (AMPA) receptor, 2,3-dihydroxy-6-nitro-7-sulfamoylbenzo(f)quinoxaline (NBQX), has been recently demonstrated [Nat. Med. 6 (2000) 67; Nat. Med. 6 (2000) 62]. However, the mechanisms underlying regulation of the extracellular(More)
In group-living primates, individuals often exchange grooming with not only kin but also non-kin. We investigated the effect of soliciting behaviors on grooming exchanges in a free-ranging Japanese macaque (Macaca fuscata) group at Katsuyama. In this study, we used a focal animal sampling method, targeting 14 females. Data were collected for 15.75 ± 2.67(More)
We report an implementation of GeneSys, which is a Web information integration system on 3D virtual space. We have built Kwansei Gakuin Kobe Sanda Campus as a virtual space called VKSC in which character agents navigate a user. VKSC reflects the Web information concerning weather, school calendar, and laboratories in the campus and the behaviour of agents(More)
A formula constituting the non-Abelian Stokes theorem for general semi-simple compact gauge groups is presented. The formula involves a path integral over a group space and is applicable to Wilson loop variables irrespective of the topology of loops. Some simple expressions analogous to the 't Hooft tensor of a magnetic monopole are given for the 2-form of(More)
The consistency condition of the Faddeev-Niemi ansatz for the gauge-fixed mass-less SU(2) gauge field is discussed. The generality of the ansatz is demonstrated by obtaining a sufficient condition for the existence of the three-component field introduced by Faddeev and Niemi. It is also shown that the consistency conditions determine this three-component(More)
The consistency condition of the Faddeev-Niemi Ansatz for the gauge-fixed mass-less SU(2) gauge field is discussed. The generality of the Ansatz is shown by obtaining a sufficient condition for the three-component field introduced by Faddeev and Niemi to exist. It is also shown that the consistency conditions determine the above three-component field as a(More)
In animal societies, the effect of grooming interactions on anxiety reduction is unclear. This study examined the effects of giving and receiving grooming on anxiety reduction in free ranging female Japanese macaques (Macaca fuscata) by measuring rates of self-scratching as an index of anxiety. In this study, the authors used a focal-animal sampling method,(More)