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  • Hideaki Tsuge, Masahiro Nagahama, +6 authors Jun Sakurai
  • Medicine, Biology
  • Proceedings of the National Academy of Sciences
  • 2008 (First Publication: 27 May 2008)
  • The ADP-ribosylating toxins (ADPRTs) produced by pathogenic bacteria modify intracellular protein and affect eukaryotic cell function. Actin-specific ADPRTs (including Clostridium perfringens ι-toxinExpand
  • Hisashi Matsuda, Tadashi Kageura, Masataka Oda, Toshio Morikawa, Yasuko Sakamoto, Masayuki Yoshikawa
  • Chemistry, Medicine
  • Chemical & pharmaceutical bulletin
  • 2001
  • The methanolic extract from a Japanese herbal medicine, the bark of Magnolia obovata, was found to inhibit nitric oxide (NO) production in lipopolysaccharide (LPS)-activated macrophages. ByExpand
  • Toshiharu Tsurumura, Yayoi Tsumori, +4 authors Hideaki Tsuge
  • Medicine, Biology
  • Proceedings of the National Academy of Sciences
  • 2012 (First Publication: 24 January 2012)
  • Clostridium perfringens iota-toxin (Ia) mono-ADP ribosylates Arg177 of actin, leading to cytoskeletal disorganization and cell death. To fully understand the reaction mechanism of arginine-specificExpand
  • Masataka Oda, Syusuke Ikari, Takayuki Matsuno, Yuka Morimune, Masahiro Nagahama, Jun Sakurai
  • Medicine, Biology
  • Infection and Immunity
  • 2006 (First Publication: 1 May 2006)
  • ABSTRACT Clostridium perfringens alpha-toxin induces the generation of superoxide anion (O2−) via production of 1,2-diacylglycerol (DG) in rabbit neutrophils. The mechanism of the generation,Expand