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Depth of invasion in early invasive colorectal cancer is considered an important predictive factor for lymph node metastasis. However, no large-scale reports have established the relationship between invasion depth of pedunculated type early invasive colorectal cancers and risk of lymph node metastasis. The aim of this retrospective cohort study was to(More)
The following studies were undertaken using specimens of submucosal invasive colorectal cancer surgically or endoscopically resected from 104 patients: 1) measurement of the depth of submucosal invasion; 2-a) histological reevaluation of colon sm cancer by scoring of the degree of histological differentiation using a modified Gleason's grading system(More)
To the Editor: In the large intestine, there is general agreement that stem cells exist at the base of the crypt, and that dysplastic cells originate in a single abnormal precursor stem cell. Thus, it is generally thought that buds of single-gland adenomas arise from the base of the crypt, and then move upward with migration of the epithelial cells of the(More)
Due to their complexity, currently available bounded model checking techniques based on Boolean Satisfiability and Satisfiability Modulo Theories inadequately handle non-linear floating-point and integer arithmetic. Using a numerical approach, we reduce a bounded model checking problem to a constraint satisfaction problem. Currently available techniques(More)
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