Masataka Kagawa

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The present study was designed to determine the effects of NIK-333, a synthetic acyclic retinoid, on N-diethylnitrosamine (DEN)-induced hepatocarcinogenesis in male F344 rats. Animals were given DEN dissolved in drinking water at a concentration of 40 p.p.m. for 5 weeks and then provided with drinking water free of DEN for 15 weeks to induce hepatocellular(More)
Intrathecal administration of neuromedin C (3, 10 nmol/rat) significantly decreased the nociceptive threshold of rats in the paw-pressure test. This effect was abolished by co-administration of [Leu13 psi(CH2NH)-Leu14]bombesin (10 nmol/rat), a bombesin receptor antagonist. Co-administration of 2-amino-5-phosphonovaleric acid (APV) at a dose (10 nmol/rat)(More)
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