• Publications
  • Influence
Pathophysiological roles of endothelin receptors in cardiovascular diseases.
TLDR
The current understanding regarding the role of ET receptors, especially the ET(B) receptor, in CVD is summarized. Expand
Endothelin-1 and Norepinephrine Overflow from Cardiac Sympathetic Nerve Endings in Myocardial Ischemia
TLDR
A detailed analysis of how the ET-1 system is involved in the regulation of carrier-mediated NE release from sympathetic nerve endings in protracted myocardial ischemia is provided. Expand
Effects of atorvastatin, amlodipine, and their combination on vascular dysfunction in insulin-resistant rats.
TLDR
It is suggested that combined therapy of HMG-CoA reductase inhibitors and calcium antagonists prevents functional vascular disorders in the insulin-resistant state, possibly resulting in the protection against or delay of development of hypertension, vascular dysfunction in diabetes, and thereafter atherosclerosis. Expand
Role of endogenous endothelin-1 in post-ischemic cardiac dysfunction and norepinephrine overflow in rat hearts.
TLDR
Cardiac endothelin-1 production is enhanced by ischemia/reperfusion, and this endogenously increased endotheli-1 is involved in post-ischemic norepinephrine overflow and cardiac dysfunction via the activation of endothelins ET(A) receptors. Expand
MicroRNA-494 plays a role in fiber type-specific skeletal myogenesis in human induced pluripotent stem cells.
TLDR
The results suggest that miR-494 plays a novel role in the fiber type-specific skeletal myogenesis in MyoD-hiPS cells, distinct from murine C2C12 myogenesis. Expand
Mechanism underlying endothelium-dependent relaxation by 2-methylthio-ADP in monkey cerebral artery.
TLDR
Findings indicate that 2MeSADP elicits 'endothelium-derived hyperpolarizing factor (EDHF)-type' relaxation via stimulation of endothelial P2Y(1) receptors in monkey cerebral artery. Expand
Angiotensin II Type 2 Receptor-Mediated Inhibition of Norepinephrine Release in Isolated Rat Hearts
TLDR
Ang II seems to function as an inhibitory modulator of cardiac noradrenergic neurotransmission via AT2Rs and well-known AT1R-mediated stimulatory actions and may involve local bradykinin production, its B2 receptor activation, and NO as a downstream effector. Expand
Effects of exogenous big endothelin-1 on postischemic cardiac dysfunction and norepinephrine overflow in rat hearts
TLDR
It is suggested that exogenous big ET-1 has beneficial effects on ischemia/reperfusion-induced cardiac injury and it seems likely that bigET-1 is converted to Et-1, locally in the heart, and this ET- 1 preferentially binds to ETB receptors to exert its related beneficial actions. Expand
Sex Differences in Postischemic Cardiac Dysfunction and Norepinephrine Overflow in Rat Heart: The Role of Estrogen Against Myocardial Ischemia–reperfusion Damage Via an NO-mediated Mechanism
TLDR
It is suggested that estrogen plays a key role in the cardioprotective effect against I/R injury in female rats, by suppressing NE release via the enhancement of NO production. Expand
Characterization of nitrergic function in monkey penile erection in vivo and in vitro
TLDR
It appears that nitric oxide released from inhibitory nerves, even at low frequencies, has a pivotal role in the initiation and maintenance of intracavernous pressure increase and penile erection in monkeys. Expand
...
1
2
3
4
5
...