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Tissue-specific knockout of the mouse Pig-a gene reveals important roles for GPI-anchored proteins in skin development.
Glycosylphosphatidylinositol (GPI)-anchored proteins are widely distributed on plasma membranes of eukaryotes. More than 50 GPI-anchored proteins have been shown to be spatiotemporally expressed inExpand
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Signal transducer and activator of transcription 3 in the heart transduces not only a hypertrophic signal but a protective signal against doxorubicin-induced cardiomyopathy.
The signal transducer and activator of transcription (STAT) 3, a transcriptional factor downstream of several cytokines, is activated by Janus kinase families and plays a pivotal role in cardiacExpand
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Functional competence of T cells in the absence of glycosylphosphatidylinositol‐anchored proteins caused by T cell‐specific disruption of the Pig‐agene
T lymphocytes express various glycosylphosphatidylinositol (GPI)‐anchored surface proteins, such as Thy‐1 and Ly‐6A. However, functional contribution of GPI‐anchored proteins in T cell activation isExpand
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Early and long-term mortality of the clinical subtypes of myocarditis.
The frequency of myocarditis and the prognosis for patients remains uncertain and, moreover, the clinical classification of myocarditis is controversial. From 1985 to 2000, 71 adult patients withExpand
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Histochemical localization of superoxide dismutase activity in rat brain.
Histochemical localization of superoxide anion (O2.-) scavenging activity in rat brain was visualized by the tissue-blotting technique. The activity was thought to mainly depend on Cu/Zn-SOD, becauseExpand
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Lymphocytic active myocarditis characterized by numerous clusters of lymphocytes: a chronic variant of myocarditis?
We report three patients with a particular form of myocarditis characterized by numerous clusters of lymphocytes. Their common clinical manifestation was progressive and fatal heart failure with a 3-Expand
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New insight into oncoprotein-targeted antitumor effect: herbimycin A as an antagonist of protein tyrosine kinase against Ph1-positive leukemia cells.
Herbimycin A, a benzoquinonoid anasamycin antibiotic, has been shown to reserve the oncogenic phenotypes of p60v-src transformed cells by the virtue of the inhibition of src protein tyrosine kinase.Expand
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Membrane cofactor protein (MCP, CD46) in seminal plasma and on spermatozoa in normal and “sterile” subjects
A sperm protein of molecular mass 43 kDa (the spermatozoa membrane cofactor protein, smMCP) and a seminal plasma protein of 60 kDa (ssMCP) were identified by sodium dodecyl sulfate‐polyacrylamide gelExpand
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Enhanced Immune Responses in Transgenic Mice Expressing a Truncated Form of the Lymphocyte Semaphorin CD1001
CD100/Sema4D is a 150-kDa transmembrane protein that belongs to the semaphorin family. Binding of CD100 to CD72 enhances the immune response by turning off the negative signaling effects of CD72. ToExpand
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Angiotensin II receptor blockade prevents microangiopathy and preserves diastolic function in the diabetic rat heart
Background: Cardiac microangiopathy may be involved in the development of heart failure in diabetes mellitus. Objective: To evaluate the effect of angiotensin II receptor blockade on cardiac functionExpand
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