Masashi Nabetani

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We investigated the correlation between energy metabolism and neural activity during glucose deprivation and during replacement of glucose with lactate and beta-hydroxybutyrate (OHBA) in neural tissue from rats of different ages. Hippocampal slices were prepared from 4-, 7-, 10-, 13- and 16-day-old and adult rats. The population spikes (PS) were recorded in(More)
To investigate the correlation between neural activity and intracellular Ca2+ ([Ca2+]i) mobilization in immature and adult brain during ischemia (hypoxia and glucose deprivation) and deprivation of glucose, hippocampal slices were prepared from 7-, 10-day-old and adult rats. Population spikes (PS) and antidromic responses (AR) were recorded in the pyramidal(More)
The protective effects of mild hypothermia (33 and 29 degrees C) on the neuronal activity, intracellular Ca2+ accumulation and ATP levels during deprivation of oxygen and/or glucose were investigated using guinea pig hippocampal slices. During oxygen and glucose deprivation and oxygen deprivation only, mild hypothermia had only minor effects on the(More)
To investigate the relationship between neural activity and cerebral energy metabolism during anoxia or ischemia in neural tissue of different ages, hippocampal slices were prepared from four-, seven- and 10-day-old and adult rats. For the index of the neural activity, the population spikes were recorded in the pyramidal cell layer of the CA3 area. ATP and(More)
We investigated the effect of fructose, mannose and lactate on the preservation of synaptic transmission in the granule cell layer of guinea pig hippocampal slices during deprivation of glucose. After replacement of glucose with lactate (5 mM) or fructose (10 mM), population spikes (PS) extinguished transiently and thereafter recovered to 60-70% of the(More)
Population spikes (PS) were recorded in the pyramidal cell layer of the CA1 and CA3 areas in hippocampal slices prepared from 4-, 7- and 10-day-old and adult rats of the Sprague-Dawley strain during brief (< 10 min) and prolonged periods (30-60 min) of oxygen deprivation (hypoxia). In mature rats, PS were depressed by hypoxia in 6.8 min in the CA1 area and(More)
BACKGROUND The aim of this study was to investigate the efficacy and safety of gemcitabine and S-1 combination chemotherapy in patients with advanced biliary tract cancer. PATIENTS AND METHODS A retrospective study was performed on 15 consecutive patients. Gemcitabine was administered intravenously at 1,000 mg/m(2) on days 8 and 15. Oral S-1 (60 mg/m(2)(More)
We have studied the clinical features and neurological sequelae in 39 cases of cerebral palsy resulting from 30 twin births. Twenty-four births (80%) occurred before 37 weeks of gestation Among 30 twin pairs, co-twin with intrauterine death in 7 pairs, both patients showed neurological sequelae in 9 pairs and one of the twins developed cerebral palsy in 14(More)
We investigated the incidence of cerebral palsy (CP) in Himeji City with a total population of about 470,000. In 1983-87 the total number of CP patients and the incidence of CP per 1,000 live births were 40 and 1.4, respectively. In 1988-92, the figures were 51 and 2.0. Periventricular leukomalacia was indicated in MRI in 11 out of 40 cases (27.5%) in(More)
Twin delivery is associated with an increased risk of cerebral palsy. (CP). We studied the incidence of CP in twins compared with singletons born from 1989 to 1994 at the district of Himeji Central Public Health Center. The incidence of CP was 1.9% in twin: 12.7 times as high as that in singletons (0.15%), and was particularly high in monozygotic twins.(More)