Masashi Kuwako

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1. The Ca2+ buffering function of sarcoplasmic reticulum (SR) in the resting state of arteries from spontaneously hypertensive rats (SHR) was examined. Differences in the effects of ryanodine that removes the function of SR, on tension and cellular Ca2+ level were assessed in endothelium-denuded strips of femoral arteries from 13-week-old SHR and(More)
Asynchronous design has a potential of solving many difficulties, such as clock skew and power consumption, which synchronous counterpart suffers with current and future VLSI technologies. This paper proposes a new delay model, the scalable-delay-insensitive (SDI) model, for dependable and high-performance asynchronous VLSI system design. Then, based on the(More)
Isolated cerebral (basilar, posterior communicating and middle cerebral) arteries exist in a partially contracted state. To determine the Ca(2+)-buffering function of sarcoplasmic reticulum in the resting state of cerebral arteries, the effects of ryanodine that eliminates the function of sarcoplasmic reticulum, on tension and cellular Ca2+ level were(More)
We report a novel drug delivery system for apoptosis induction by a "smart" polymer vehicle possessing thermosensitivity and bioaffinity. The polymer chain was prepared by copolymerization of N-isopropylacrylamide and N-methacryloyloxysuccinimide. Cell-adhesive RGDS peptide was conjugated with the copolymer as a ligand model for bioaffinity. When the(More)
only on the causal relation of signal transitions with an average delay in-DeIa y-l nsens i tive Microprocessor MODERN DEVICE technology enables logic gates with a switching delay of only a few picosec-onds. But because no signal can reach further than 0.3 mm in 1 ps, the use of such fast switching devices presents serious timing problems , namely wire(More)
A sustained Ca2+ influx via L-type Ca2+ channels has been shown in the resting state of dog cerebral arteries. Sarcoplasmic reticulum is now recognized to serve as a buffer barrier to Ca2+ entry in vascular smooth muscle cells. To clarify whether sarcoplasmic reticulum of the cerebral arteries can buffer the sustained Ca2+ influx, effects of cyclopiazonic(More)
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