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The ubiquitin ligase CHIP acts as an upstream regulator of oncogenic pathways
CHIP is a U-box-type ubiquitin ligase that induces ubiquitylation and degradation of its substrates, which include several oncogenic proteins. The relationship between CHIP and tumour progression,Expand
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Estrogen Inhibits Transforming Growth Factor β Signaling by Promoting Smad2/3 Degradation*
Estrogen is a growth factor that stimulates cell proliferation. The effects of estrogen are mediated through the estrogen receptors, ERα and ERβ, which function as ligand-induced transcriptionExpand
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The E3 Ubiquitin Ligase Activity of Trip12 Is Essential for Mouse Embryogenesis
Protein ubiquitination is a post-translational protein modification that regulates many biological conditions [1], [2], [3], [4]. Trip12 is a HECT-type E3 ubiquitin ligase that ubiquitinates ARF andExpand
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