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UNLABELLED We isolated and expanded BMSCs from human alveolar/jaw bone at a high success rate (70%). These cells had potent osteogenic potential in vitro and in vivo, although their chondrogenic and adipogenic potential was less than that of iliac cells. INTRODUCTION Human bone marrow stromal cells (BMSCs) have osteogenic, chondrogenic, and adipogenic(More)
Bone marrow stromal cells (BMSCs) are valuable in tissue engineering and cell therapy, but the quality of the cells is critical for the efficacy of therapy. To test the quality and identity of transplantable cells, we identified the molecular markers that were expressed at higher levels in BMSCs than in fibroblasts. Using numerous BMSC lines from tibia,(More)
To characterize mesenchymal stem cells (MSC), we compared gene expression profiles in human bone marrow MSC (11 lines) and human fibroblasts (4 lines) by RT-PCR and real time PCR. Messenger RNA levels of MHC-DR-alpha, MHC-DR-beta, MHC-DR-associated protein CD74, tissue factor pathway inhibitor-2, and neuroserpin were much higher in MSC than in fibroblasts,(More)
OBJECTIVE Our aim was to clarify the association of human papillomavirus (HPV) with oral carcinogenesis, especially its early stage. STUDY DESIGN Tissue specimens of normal mucosa, epithelial dysplasia, oral squamous cell carcinoma (OSCC), and OSCC cell lines were examined for the presence of HPV-16 and HPV-18 E6 DNA by means of the polymerase chain(More)
OBJECTIVES The receptor for advanced glycation end products (RAGE) is a newly recognized factor regulating cancer cell invasion and metastasis. Nevertheless, the involvement of RAGE in the development and progression of oral squamous cell carcinomas has not been elucidated. This study investigated the expression of RAGE in ten oral squamous cell carcinoma(More)
PURPOSE The present study was conducted to investigate the biomechanical response of bovine retrodiscal tissue of the temporomandibular joint (TMJ) in compression. PATIENTS AND METHODS Using 10 retrodiscal tissues obtained from 10 cattle, the viscoelastic response of the retrodiscal tissue was evaluated by means of stress-strain analyses. These(More)
BACKGROUND Oral human papillomavirus (HPV) infection is associated with oral cancer development. However, few epidemiologic investigations have focused on oral HPV prevalence in healthy individuals. The objective of this study was to provide updated information regarding oral HPV prevalence in patients without oral cancer worldwide. METHODS We(More)
PURPOSE This study was designed to investigate the effects of artificial mechanical separation of the circummaxillary sutures on craniofacial growth in growing rats. MATERIALS AND METHODS Twenty 4-week-old Wistar strain male rats were divided equally into experimental and control groups. In the experimental group, 4 holes were made on the maxillary and(More)
OBJECTIVE Extracellularly released high mobility group box 1 (HMGB1) protein behaves as a cytokine, promotes inflammation and participates in the pathogenesis of several disorders in peripheral organs. The role of HMGB1 and receptor for advanced glycation end products (RAGE) expressed in gingival inflammatory tissues was explored. METHODS Real time PCR(More)
A rare case is described of a solitary fibrous tumor (SFT) with malignant potential arising in the sublingual gland. A 59-year-old man presented with a 4-month history of a slowly enlarging painless mass in the center of the floor of the mouth. The tumor was a well-demarcated, firm mass with a multicystic lesion. The tumor exhibited highly cellular areas of(More)