Masao Morimoto

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Enaminones are synthesized by the rhodium(II)-catalyzed denitrogenative rearrangement reaction of 1-(N-sulfonyl-1,2,3-triazol-4-yl)alkanols, which are readily prepared from propargylic alcohols and N-sulfonyl azides. Intramolecular 1,2-hydride (or -alkyl) migration occurs with an intermediary α-imino rhodium(II) carbenoid species generated through(More)
We report a highly diastereo- and enantioselective synthesis of anti homoallylic alcohols from terminal alkynes via (E)-1-alkenylboronates based upon two catalytic reactions: a cationic iridium complex-catalyzed olefin transposition of (E)-1-alkenylboronates and a chiral phosphoric acid-catalyzed allylation reaction of aldehydes.
Aliphatic terminal alkenes react with pinacolborane at ambient temperature to afford dehydrogenative borylation compounds as the major product when iPr-Foxap is used as the ligand with cationic rhodium(I) in the presence of norbornene, which acts as the sacrificial hydrogen acceptor. The reaction is applied to the one-pot syntheses of aldehydes and(More)
1,2,3-Benzotriazin-4(3H)-ones react with 1,3-dienes in the presence of a nickel(0)/phosphine complex to give a variety of 3,4-dihydroisoquinolin-1(2H)-ones. Oxidative insertion of nickel(0) into the triazinone moiety prompts extrusion of dinitrogen to give a five-membered ring azanickelacyclic intermediate. Subsequent insertion of 1,3-dienes into the(More)
The structures of diastereomeric pairs consisting of (S)- and (R)-2-methylpiperazine with (2S,3S)-tartaric acid are both 1:1 salts, namely (S)-2-methylpiperazinium (2S,3S)-tartrate dihydrate, C(5)H(14)N(2)(2+).C(4)H(4)O(6)(2-).2H(2)O, (I), and (R)-2-methylpiperazinium (2S,3S)-tartrate dihydrate, C(5)H(14)N(2)(2+).C(4)H(4)O(6)(2-).2H(2)O, (II), which reveal(More)
The crystal structures of a pair of diastereomeric 1:2 salts of (R)- and (S)-2-methylpiperazine with (2S,3S)-tartaric acid, namely (R)-2-methylpiperazinediium bis[hydrogen (2S,3S)-tartrate] monohydrate, (I), and (S)-2-methylpiperazinediium bis[hydrogen (2S,3S)-tartrate] monohydrate, (II), both C(5)H(14)N(2)(2+).2C(4)H(5)O(6)(-).H(2)O, each reveal the(More)
Mitomycin C (MMC) showed a wide antitumor spectrum with regression of various tumors and the optimal schedule of a single or intermittent administration against human tumor cells xenografted to nude mice, confirming the early reports obtained in rodent tumor system. The sensitivity of various human tumors xenografted to nude mice has been tested to(More)
The aromatization of 2-octanol derived from castor oil as a byproduct in the formation of sebacic acid was investigated on various zeolite catalysts. Zn ion-exchanged MFI (ZSM-5) zeolites with small silica/alumina ratios and zinc contents of 0.5 to 2.0 wt. % were determined to exhibit good and stable activity for the reaction at 623 to 823 K. The yield of(More)