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Synthesis and biological evaluation of radioiodinated quinacrine-based derivatives for SPECT imaging of Aβ plaques.
- Takeshi Fuchigami, N. Kobashi, M. Haratake, Masao Kawasaki, Morio Nakayama
- Chemistry, Medicine
- European journal of medicinal chemistry
- 1 February 2013
The aim of the present study was to characterize the binding property of quinacrine-based acridine derivatives for Aβ plaques and to evaluate this series of compounds as Aβ imaging probes. Quinacrine… Expand
Development of alkoxy styrylchromone derivatives for imaging of cerebral amyloid-β plaques with SPECT.
- Takeshi Fuchigami, Ayaka Ogawa, +6 authors Morio Nakayama
- Chemistry, Medicine
- Bioorganic & medicinal chemistry letters
- 15 August 2015
We report here the development of radioiodinated styrylchromone derivatives with alkoxy groups as single photon emission computed tomography (SPECT) imaging probes for cerebral amyloid-β (Aβ)… Expand
Characterisation of radioiodinated flavonoid derivatives for SPECT imaging of cerebral prion deposits
- Takeshi Fuchigami, Y. Yamashita, +10 authors Morio Nakayama
- Chemistry, Medicine
- Scientific reports
- 16 December 2015
Prion diseases are fatal neurodegenerative diseases characterised by deposition of amyloid plaques containing abnormal prion protein aggregates (PrPSc). This study aimed to evaluate the potential of… Expand
Development of radioiodinated acridine derivatives for in vivo imaging of prion deposits in the brain.
- Masao Kawasaki, Takeshi Fuchigami, +7 authors Morio Nakayama
- Chemistry, Medicine
- Bioorganic & medicinal chemistry
- 1 February 2017
Prion diseases are caused by deposition of abnormal prion protein aggregates (PrPSc) in the central nervous system. This study aimed to develop in vivo imaging probes that can detect cerebral PrPSc… Expand
Development of Radioiodinated Benzofuran Derivatives for in Vivo Imaging of Prion Deposits in the Brain.
- Takeshi Fuchigami, Masao Kawasaki, +9 authors Morio Nakayama
- Chemistry, Medicine
- ACS infectious diseases
- 15 March 2019
Prion diseases are fatal neurodegenerative disorders associated with the deposition of abnormal prion protein aggregates (PrPSc) in the brain tissue. Here, we report the development of 125I-labeled… Expand
Feasibility studies of radioiodinated pyridyl benzofuran derivatives as potential SPECT imaging agents for prion deposits in the brain.
- Takeshi Fuchigami, Masao Kawasaki, +9 authors Morio Nakayama
- Chemistry, Medicine
- Nuclear medicine and biology
- 15 September 2020
INTRODUCTION
Prion diseases are fatal neurodegenerative disorders caused by the deposition of abnormal prion protein aggregates (PrPSc) in the central nervous system. This study aimed to evaluate the… Expand
Title Characterisation of radioiodinated flavonoid derivatives for SPECTimaging of cerebral prion deposits
- Takeshi Fuchigami, Y. Yamashita, +10 authors Morio Nakayama
- 2016
Right This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons… Expand