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Synthesis and biological evaluation of radioiodinated quinacrine-based derivatives for SPECT imaging of Aβ plaques.
The aim of the present study was to characterize the binding property of quinacrine-based acridine derivatives for Aβ plaques and to evaluate this series of compounds as Aβ imaging probes. QuinacrineExpand
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Development of alkoxy styrylchromone derivatives for imaging of cerebral amyloid-β plaques with SPECT.
We report here the development of radioiodinated styrylchromone derivatives with alkoxy groups as single photon emission computed tomography (SPECT) imaging probes for cerebral amyloid-β (Aβ)Expand
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Characterisation of radioiodinated flavonoid derivatives for SPECT imaging of cerebral prion deposits
Prion diseases are fatal neurodegenerative diseases characterised by deposition of amyloid plaques containing abnormal prion protein aggregates (PrPSc). This study aimed to evaluate the potential ofExpand
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Development of radioiodinated acridine derivatives for in vivo imaging of prion deposits in the brain.
Prion diseases are caused by deposition of abnormal prion protein aggregates (PrPSc) in the central nervous system. This study aimed to develop in vivo imaging probes that can detect cerebral PrPScExpand
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Development of Radioiodinated Benzofuran Derivatives for in Vivo Imaging of Prion Deposits in the Brain.
Prion diseases are fatal neurodegenerative disorders associated with the deposition of abnormal prion protein aggregates (PrPSc) in the brain tissue. Here, we report the development of 125I-labeledExpand
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Feasibility studies of radioiodinated pyridyl benzofuran derivatives as potential SPECT imaging agents for prion deposits in the brain.
INTRODUCTION Prion diseases are fatal neurodegenerative disorders caused by the deposition of abnormal prion protein aggregates (PrPSc) in the central nervous system. This study aimed to evaluate theExpand
Title Characterisation of radioiodinated flavonoid derivatives for SPECTimaging of cerebral prion deposits
Right This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative CommonsExpand