Masanori Yamazaki

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Epstein-Barr virus-induced gene-3 (EBI-3) associates with p28 to form interleukin-27 (IL-27) or with IL-12p35 to form IL-35. Both IL-27 and IL-35 have immunosuppressive functions and especially IL-35 has been implicated in the suppressive function of regulatory T cells (Treg). To address the role of EBI-3 in immune regulation, delayed-type hypersensitivity(More)
An increasing number of neurologic diseases is associated with autoimmunity. The immune effectors contributing to the pathogenesis of such diseases are often unclear. To explore whether self-reactive CD8 T cells could attack CNS neurons in vivo, we generated a mouse model in which the influenza virus hemagglutinin (HA) is expressed specifically in CNS(More)
A variety of reactive organic compounds, called haptens, can cause allergic contact dermatitis. However, the innate immune mechanisms by which haptens stimulate dendritic cells (DCs) to sensitize T cells remain unclear. Here we show that the coupling of ITAM-Syk-CARD9 signalling to interleukin-1 (IL-1) secretion in DCs is crucial for allergic sensitization(More)
CARMA1-mediated NF-κB activation controls lymphocyte activation through antigen receptors and survival of some malignant lymphomas. CARMA1 clusters are formed on physiological receptor-mediated activation or by its oncogenic mutation in activated B-cell-diffuse large B-cell lymphomas (ABC-DLBCLs) with constitutive NF-κB activation. However, regulatory(More)
Network services based on distributed components, which provide advanced network services with lower cost by flexibly assigning and reusing useful components running on remote servers, are attracting increasing attention. In this study, we propose a new platform which provides sustainable QoS and faster service time by allocating components dynamically with(More)
Recently, network services based on distributed components that provide services by using components running on remote nodes have attracted much attention. Advanced services can be provided at a lower cost by using existing components. We have previously proposed a method that ensures a stable QoS for each service by allocating components dynamically(More)
Recently, advanced network services have been provided by assortment of distributed components at low cost. However, network elements are not considered in such a framework. In this paper, we propose a new service platform which unifies componentized network control function. This platform aims to provide advanced services flexibly according to the(More)
Oligomycin antibiotics, 44-homooligomycin A (NK86-0279 II) and B (NK86-0279 I) are newly discovered antitumor antibiotics with the substitution of ethyl for methyl at carbon 26. They were isolated from the culture broth of Streptomyces bottropensis NK86-0279. The structure of these two compoundswas deduced by spectroscopic and X-ray crystallographic(More)
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