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Type I IFN Induces Binding of STAT1 to Bcl6: Divergent Roles of STAT Family Transcription Factors in the T Follicular Helper Cell Genetic Program
- S. Nakayamada, A. Poholek, +10 authors J. O’Shea
- Biology, Medicine
- The Journal of Immunology
- 1 March 2014
It is shown that type I IFNs (IFN-α/β) induced B cell lymphoma 6 (Bcl6) expression, the master regulator transcription factor for TFH cells, and CXCR5 and programmed cell death-1 (encoded by Pdcd1), key surface molecules expressed byTFH cells. Expand
Efficient delivery of antibody into living cells using a novel HVJ envelope vector system.
- Y. Kondo, Kuni Fushikida, +4 authors Masanari Kato
- Medicine, Biology
- Journal of immunological methods
- 20 March 2008
A new method for intracellular delivery of antibody using a combination of a novel IgG-capturing protein and hemagglutinating virus of Japan envelope and an inactivated Sendai virus particle which can deliver a variety of molecules into mammalian cells via membrane-fusing activity is developed. Expand
Novel Mutein of Tumor Necrosis Factor α (F4614) with Reduced Hypotensive Effect
Results indicated that F4614 has several advantages as a systemic therapeutic drug in the treatment of cancer, and evidence that the Arg → Val mutation at position 29 is largely responsible for the reduced hypotensive effect is presented. Expand
Novel Biological Response Modifiers: Phthalimides with Tumor Necrosis Factor-α Production-Regulating Activity.
Relationship between the tautomeric structures of curcumin derivatives and their Abeta-binding activities in the context of therapies for Alzheimer's disease.
The findings of this study suggest that curcumin derivatives exist predominantly in the enol form during binding to Abeta aggregates, and that theEnolization of cur cumin derivatives is crucial for binding toAbeta aggregation fibrils. Expand
Effective magnetic labeling of transplanted cells with HVJ-E for magnetic resonance imaging
The results indicate that the hemagglutinating virus-envelope is a powerful tool for magnetic labeling and can be used to incorporate paramagnetic Fe3+ particles into PC12 cells and astrocytes. Expand
Trifluoromethoxy-benzylated ligands improve amyloid detection in the brain using 19F magnetic resonance imaging
- T. Amatsubo, S. Morikawa, +12 authors I. Tooyama
- Chemistry, Medicine
- Neuroscience Research
- 31 January 2009
The results indicate that the inhibitory effect of brain tissue on the (19)F NMR signals from these probes can be attributed to the hydrophobicity of the tissue. Expand
Noncytotoxic ribonuclease, RNase T1, induces tumor cell death via hemagglutinating virus of Japan envelope vector.
- S. Yuki, Y. Kondo, F. Kato, Masanari Kato, N. Matsuo
- Medicine, Biology
- European journal of biochemistry
- 1 September 2004
This study internalized RNase T1 into human tumor cells via a novel gene transfer reagent, hemagglutinating virus of Japan (HVJ) envelope vector, which resulted in cell death and cytotoxicity was drastically increased by pretreatment of HVJ envelope vector with protamine sulfate. Expand
A Novel Synthetic Anti-Acute Pancreatitis Agent, IS-741
A novel synthetic drug, IS-741, inhibited cell adhesion in vitro and neutrophil in vivo and demonstrated various anti-acute pancreatitis effects by interrupting a vicious cycle of inflammation and is expected to become a useful drug for treating acute pancreatitis and multiple organ failure in clinical settings. Expand
Binding form of curcumin derivatives to β-amyloid aggregates