Masami Takagaki

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BACKGROUND Insertion of an implantable left ventricular assist device (LVAD) complicated by early right ventricular (RV) failure has a poor prognosis and is largely unpredictable. Prediction of RV failure after LVAD placement would lead to more precise patient selection and optimal device selection. METHODS AND RESULTS We reviewed data from 245 patients(More)
OBJECTIVE An animal model of chronic severe heart failure is needed to evaluate new mechanical devices, surgical procedures, and medical therapies. The purpose of this study was to evaluate a unique new model of severe heart failure developed by means of a novel protocol of rapid ventricular pacing. METHODS Heart failure was induced in 8 mongrel dogs by(More)
Dipeptidyl peptidase II (DPP II) was purified to homogeneity from porcine seminal plasma by polyacrylamide gel electrophoresis (PAGE). The molecular weight of the purified enzyme was calculated to be approx. 185,000 and 200,000 on Superdex 200 column chromatography and non-denatured PAGE, respectively, and to be 58,000 and 61,000 on SDS-PAGE in the absence(More)
OBJECTIVES The aim of this work was to determine whether mitral valve (MV) annuloplasty benefits patients with moderate/severe (3+/4+) functional ischemic mitral regurgitation (MR) who undergo coronary artery bypass grafting (CABG). BACKGROUND Mitral regurgitation is a strong predictor of poor outcomes in patients with ischemic cardiomyopathy; whether(More)
BACKGROUND We developed a total right ventricular (RV) exclusion procedure for the treatment of isolated congestive RV failure. The objective of the present study was to elucidate the effects of a complete removal of RV volume overload (RVVO) on the surgically created single left ventricle (LV). METHODS AND RESULTS Three adults (2 arrhythmogenic RV(More)
OBJECTIVE The Damus-Kaye-Stansel operation sometimes results in deteriorating semilunar valve insufficiency. We verified the semilunar valve function after the Damus-Kaye-Stansel operation and compared the end-to-side Damus-Kaye-Stansel with the double-barrel Damus-Kaye-Stansel. METHODS Forty-seven patients who underwent the Damus-Kaye-Stansel operation(More)
A 70-year-old woman was admitted to our institution with acute myocardial infarction. Coronary angiography demonstrated total occlusion of the left anterior descending artery, which was successfully revascularized. Four days later, the patient suddenly went into shock. The subsequent emergency operation revealed a blowout rupture of the left ventricular(More)
An amino acid sequence (Arg-Gly-Asp-Val) specifically associating with cell adhesion between cells and extracellular matrices was found on the human Zn-alpha 2-glycoprotein (Zn alpha 2gp) molecule. Although other mammalian cell lines such as breast carcinoma and melanoma did not, SMKT R-3 cells (human renal cell carcinoma) but not the kidney cell lines(More)
BACKGROUND Left ventricular contractility in atrial fibrillation is known to change in a beat to beat fashion, but there is no gold standard for contractility indices in atrial fibrillation, especially those measured non-invasively. OBJECTIVE To determine whether the non-invasive index of contractility "preload-adjusted PWR(max)" (maximal ventricular(More)
BACKGROUND Severe patient-prosthesis mismatch, defined as effective orifice area index ≤0.65 cm(2) m(-2), has demonstrated poor long-term survival after aortic valve replacement. Reported rates of severe mismatch involving the Perimount Magna aortic bioprosthesis range from 4% to 20% in patients with a small annulus. METHODS Between June 2008 and August(More)