Masami Obara

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Alzheimer's disease (AD) is characterized by amyloid-β (Aβ) protein and tau deposition in the brain. Numerous studies have reported a central role of Aβ in the development of AD, but the pathogenesis is not well understood. Collapsin response mediator protein 2 (CRMP2), an intracellular protein mediating a repulsive axon guidance molecule, Semaphorin3A, is(More)
À / À embryos (Supplementary Figure 2g). Flow cytomery analysis on fetal liver cells revealed that overall fetal hematopoiesis in Pten À / À mice was normal, except a skewed lymphoid/myeloid development at the progenitor level. There was no reduction in the hematopoietic stem cell-enriched lin À sca-1 þ c-kit þ population. However, there was an increased(More)
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