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We investigated the efficacy and safety of switching to insulin glulisine (GLU) from other rapid-acting insulin analogs (Ra) in children with type 1 diabetes treated with multiple daily injections of insulin or continuous subcutaneous insulin infusion. A total of 26 children with type 1 diabetes were included. Ra in all of these patients was changed to GLU,(More)
We investigated the percentage of total basal insulin dose to total daily insulin dose (%TBD) among Japanese youth of different ages with type 1 diabetes. The study enrolled 69 patients with type 1 diabetes who were treated with multiple daily injections of insulin. The participants were divided into the following age groups: group A, 0 to <10 years (n =(More)
Aims We defined the dawn phenomenon is an increase in either insulin requirements or the plasma glucose concentration, in the absence of preceding hypoglycemia or waning insulin levels, occurring between the hours of 0400 and 0800. According to previous studies, the frequency of dawn phenomenon is reported to be approximately 54.0% inpatients with type 1(More)
Sulfonylureas (SUs) are recommended as the first-line pharmacological treatment in patients with uncontrolled maturity-onset diabetes of the young type 3 (MODY3). In contrast, glucagon-like peptide-1 (GLP-1) receptor agonists have the advantages of a low risk of hypoglycemia and maintained β-cell function. We report a pediatric patient with MODY3 treated(More)
The risks of complications due to chronic diabetes are indicated by an increase in average blood glucose levels and the range of blood glucose level fluctuation. Postpran-dial hyperglycemia should be the target of glycemic control in clinical practice. There are few studies on the time to peak postprandial glucose levels in children. Therefore, we(More)
We treated 80 obese and 28 nonobese children diagnosed as having type 2 diabetes mellitus (T2DM). Among these patients, 26 obese and 23 nonobese children were assigned to pharmacologic therapies during the course of diabetes. Pharmacologic therapies were started if the HbA1c (NGSP) value exceeded 7.0% despite dietary and exercise management. For the 26(More)
BACKGROUND Insulin resistance at diagnosis was investigated in Japanese children with type 2 diabetes mellitus (T2DM). METHODS A total of 160 children with T2DM were divided into groups on the basis of percent overweight at time of diagnosis: group A (n = 28), <20%; group B (n = 55), 20-39%; group C (n = 37), 40-59%; group D (n = 40), ≥ 60%. Indicators of(More)
AIMS We examined the clinical characteristics of non-obese Japanese children with type 2 diabetes mellitus (T2DM) not associated with β-cell autoimmunity. METHODS Of 218 children who were diagnosed as having T2DM by a school urine glucose screening program in Tokyo, 24 were identified as being non-obese and were enrolled in this study. None of the(More)
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