Masaki Wakabayashi

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We performed post-mortem examinations of three patients with progressive neurogenic amyotrophy of long duration. One patient had been clinically diagnosed as having sporadic amyotrophic lateral sclerosis (ALS) and two had been diagnosed with progressive spinal muscular atrophy (PSMA). The disease durations were 10, 17 and 20 years, respectively, and all of(More)
Synapsins are neuronal phosphoproteins that coat synaptic vesicles and are believed to function in the regulation of neurotransmitter release. The signaling mechanism for short-chain free fatty acid (SCFA)-stimulated NE release was examined using primary-cultured mouse sympathetic cervical ganglion neurons. Pharmacological and knockdown experiments showed(More)
The uptake of 14C-GABA and 14C-choline by cerebral cortex slices did not show any change in rats which showed neurological signs 7 days after the last 7 methylmercury injections (10 mg/kg/day). However, 14C-GABA uptake by dorsal ganglia greatly decreased, although 14C-choline uptake did not decrease in dorsal ganglia. 14C-GABA uptake by cerebellum also was(More)
Joseph's disease is a hereditary ataxia found among descendants of Portuguese from the Azores Islands. We describe the clinical and pathological features of 4 members of a Japanese family who were diagnosed as having Joseph's disease. The illness began with cerebellar ataxia between the ages of 18 and 45 years. Nystagmus, dysarthria, and pyramidal signs(More)
A massively parallel processor called JUMP-1 has been developed to build an efficient cache coherent-distributed shared memory (DSM) on a large system with more than 1000 processors. Here, the dedicated processor called MBP (Memory Based Processor)-light to manage the DSM of JUMP-1 is introduced, and its preliminary performance with two protocol policies(More)
Studies of cell inactivation kinetics by anticancer agents are important in providing a rational basis for treatment schedules. For several years, we have reported various aspects of the survival response of mammalian cells to Bleomycin (BLM) (Terasima et al., 1972; Takabe et al., 1977). The dose-survival response of cells to BLM was characterized by an(More)
Zinc signaling and dynamics play significant roles in many physiological responses and diseases. To understand the physiological roles of zinc in detail, comprehensive identification of proteins under high concentration of mobile zinc ion is crucial. We developed a 'conditional proteomics' approach to identify proteins involved in zinc homeostasis based on(More)
Preface The gamma function was introduced in the era of Euler and Gauss. This function had played fundamental roles in the theory of special functions. Basic properties of the gamma function are well known in the theory of classical analysis. For example, we can see that it has infinite product representations, that it satisfies the Bohr-Morellup theorem(More)
A massively parallel processor called JUMP-1 has been developed to build an efficient cache coherent-distributed shared memory (DSM) on a large system with more than 1000 processors. Here, the dedicated processor called MBP (Memory Based Processor)-light to manage the DSM of JUMP-1 is introduced, and its preliminary performance with two protocol policies(More)