Masaki Sano

Naoki Unno6
Nobuhiro Zaima4
6Naoki Unno
4Nobuhiro Zaima
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Biological processes are governed by complex networks ranging from gene regulation to signal transduction. Positive feedback is a key element in such networks. The regulation enables cells to adopt multiple internal expression states in response to a single external input signal. However, past works lacked a dynamical aspect of this system. To address the(More)
BACKGROUND In the absence of stimuli, most motile eukaryotic cells move by spontaneously coordinating cell deformation with cell movement in the absence of stimuli. Yet little is known about how cells change their own shape and how cells coordinate the deformation and movement. Here, we investigated the mechanism of spontaneous cell migration by using(More)
Algorithms where offsprings (new search points) are generated according to the estimated probability model of the good parents are called the Probabilistic Model-Building Genetic Algorithms (PMBGAs). In this paper, a new model of PMBGA, Distributed PMBGA (DPMBGA), is proposed. In the DPMBGA, the correlation between the design variables is considered by PCA(More)
The pathogenesis of abdominal aortic aneurysm (AAA) is characterized to be inflammation-associated degeneration of vascular wall. Neovascularization is regularly found in human AAA and considered to play critical roles in the development and rupture of AAA. However, little is known about lymphangiogenesis in AAA. The purpose of this study was to demonstrate(More)
OBJECTIVE To investigate the myelination progression course in language-correlated regions of children with normal brain development by quantitative magnetic resonance imaging (MRI) analysis compared with histological studies. METHODS The subjects were 241 neurologically intact neonates, infants and young children (128 boys and 113 girls) who underwent(More)
Abdominal aortic aneurysm (AAA) is a common disease among elderly individuals. However, the precise pathophysiology of AAA remains unknown. In AAA, an intraluminal thrombus prevents luminal perfusion of oxygen, allowing only the adventitial vaso vasorum (VV) to deliver oxygen and nutrients to the aortic wall. In this study, we examined changes in the(More)
Stochastic motion of a point - known as Brownian motion - has many successful applications in science, thanks to its scale invariance and consequent universal features such as Gaussian fluctuations. In contrast, the stochastic motion of a line, though it is also scale-invariant and arises in nature as various types of interface growth, is far less(More)
CONCLUSIONS This study showed that delayed auditory pathway myelination is common in Pelizaeus-Merzbacher disease (PMD), but this delay does not necessarily indicate poor hearing function. OBJECTIVE PMD is a rare recessively inherited X-linked leukodystrophy characterized by defective central nervous system myelination owing to a mutation in the(More)
The thermodynamic formalism for dynamical systems with many degrees of freedom is extended to deal with time averages and fluctuations of some macroscopic quantity along typical orbits, and applied to coupled map lattices exhibiting phase transitions. Thereby, it turns out that a seed of phase transition is embedded as an anomalous distribution of unstable(More)