Masaki Sano

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Biological processes are governed by complex networks ranging from gene regulation to signal transduction. Positive feedback is a key element in such networks. The regulation enables cells to adopt multiple internal expression states in response to a single external input signal. However, past works lacked a dynamical aspect of this system. To address the(More)
BACKGROUND In the absence of stimuli, most motile eukaryotic cells move by spontaneously coordinating cell deformation with cell movement in the absence of stimuli. Yet little is known about how cells change their own shape and how cells coordinate the deformation and movement. Here, we investigated the mechanism of spontaneous cell migration by using(More)
The effect of acute hypertension, induced in rats by intravenous injection of methoxamine chloride (Mexan), on the stria vascularis and spiral ligament was studied electronmicroscopically with the tracer method of horseradish peroxidase (HRP). Considerable extravasation of HRP occurred in the stria vascularis, due to the increased vesicular transport. The(More)
OBJECTIVE To investigate the myelination progression course in language-correlated regions of children with normal brain development by quantitative magnetic resonance imaging (MRI) analysis compared with histological studies. METHODS The subjects were 241 neurologically intact neonates, infants and young children (128 boys and 113 girls) who underwent(More)
Algorithms where offsprings (new search points) are generated according to the estimated probability model of the good parents are called the Probabilistic Model-Building Genetic Algorithms (PMBGAs). In this paper, a new model of PMBGA, Distributed PMBGA (DPMBGA), is proposed. In the DPMBGA, the correlation between the design variables is considered by PCA(More)
OBJECTIVE We aimed to quantitatively determine whether middle ear inflammation associated with unilateral chronic otitis media (COM), cholesteatoma, or otosclerosis affects gustatory function. STUDY DESIGN Prospective study. SETTING University Hospital, Department of Otolaryngology. PATIENTS Forty-two patients had unilateral COM (22 men, 20 women;(More)
OBJECTIVE The purpose of this study is to investigate the early myelination patterns of brainstem auditory nuclei and pathway on magnetic resonance imaging compared with past histological research. We aimed to identify the time course difference in myelination of the brainstem auditory nuclei and pathway between magnetic resonance imaging and histological(More)
The pathogenesis of abdominal aortic aneurysm (AAA) is characterized to be inflammation-associated degeneration of vascular wall. Neovascularization is regularly found in human AAA and considered to play critical roles in the development and rupture of AAA. However, little is known about lymphangiogenesis in AAA. The purpose of this study was to demonstrate(More)
Stochastic motion of a point - known as Brownian motion - has many successful applications in science, thanks to its scale invariance and consequent universal features such as Gaussian fluctuations. In contrast, the stochastic motion of a line, though it is also scale-invariant and arises in nature as various types of interface growth, is far less(More)