Masaki Nishiuchi

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Neuroblastoma rarely occurs in adults, in whom prognosis is poor. Here we report on the effective use of multimodal therapy to achieve long-term survival in adult mediastinal neuroblastoma. In a 33-year-old male with severe pain radiating from the left hypochondrium to the back area, no abnormal shadow was detected on first examination; the shadow appeared(More)
Homologous (mouse) and heterologous (human) recombinant interferon-gamma (IFN-gamma) interferons were injected intravenously into C57BL/6 mice. After 5 min, the greatest proportion of the human IFN was found in the liver, whereas no mouse IFN was detected in the liver at this time or later. Similar results were found in rats, hamsters, and cynomolgus(More)
The palladium-catalyzed coupling reaction of 6-iodoisoflavone, prepared from 3'-iodoacetophenone derivative, with 2-methyl-3-butyn-2-ol gave 6-alkynylisoflavone derivative, which was hydrogenated to give 6-alkylhydroxyisoflavone (luteone hydrate) (2). Dehydration of 2 gave 2',4',5,7-tetrahydroxy-6-prenylisoflavone (luteone) (1). Wighteone hydrate (3) was(More)
As betamethasone 17,21-dipropionate induces adrenal atrophy in rat dams and adrenal hypertrophy in the fetus, we investigated the placental transfer of this compound using autoradiography and liquid scintillation counting in animals in the late stages of pregnancy. In these two species, 3H-betamethasone 17,21-dipropionate and/or its metabolites transferred(More)
The reaction of tetraarylbutatrienes (tetraaryl[3]cumulenes) with tetracyanoethene (TCNE), a strong electron-accepting molecule, at room temperature yielded novel four-membered ring compounds (head-to-tail unsymmetrically substituted diarylallene dimers) by [2 + 2] cycloaddition of the central C=C bond of the butatrienes. This reaction proceeded through a(More)
The effects of metabolites of betamethasone 17,21-dipropionate (BMDP) on the hypothalamo-pituitary-adrenocortical axis were assessed by measurements of adrenal weights, after studying the metabolism of BMDP in vivo and in vitro in pregnant rats and mice. After BMDP was injected intravenously at a dose of 5 mg/kg into rats and mice in late stages of(More)
Bronchoplasty originally designed for patients with inadequate pulmonary function who cannot tolerate pneumonectomy, has recently yielded good results as well as offering an alternative to pneumonectomy. We describe a technique for plication of the proximal bronchial membranous portion when there is significant discrepancy in lumen size between the main and(More)
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