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In this paper, we describe the architecture and performance of the GRAPE-6 system, a massivelyparallel special-purpose computer for astrophysical N -body simulations. GRAPE-6 is the successor of GRAPE-4, which was completed in 1995 and achieved the theoretical peak speed of 1.08 Tflops. As was the case with GRAPE-4, the primary application of GRAPE-6 is(More)
As an entry for the 2000 Gordon Bell performance prize, we report the performance achieved on a prototype GRAPE-6 system. GRAPE-6 is a special-purpose computer for astrophysical N-body calculations. The present configuration has 96 custom pipeline processors, each containing six pipeline processors for the calculation of gravitational interactions between(More)
Shear stress stimulus is expected to enhance angiogenesis, the formation of microvessels. We determined the effect of shear stress stimulus on three-dimensional microvessel formation in vitro. Bovine pulmonary microvascular endothelial cells were seeded onto collagen gels with basic fibroblast growth factor to make a microvessel formation model. We observed(More)
Neuroblastoma, which is a malignant tumor consisting of dedifferentiated neuroectodermal cells, is known to show spontaneous maturation or regression in its growth. Cultured human neuroblastoma GOTO cells could be induced to differentiate into Schwannian cells and neuronal cells by incubation in the presence of 5-bromo-2'-deoxyuridine (BrdU) and by serum(More)
Endothelial progenitor cell (EPC) transplantation is a promising treatment option for ischemic diseases, and understanding the mechanism mediating angiogenic effects of EPCs is essential to further improve its effectiveness as well as their application to in vitro tissue engineering. Here we investigated EPC contribution on network formation using an in(More)
A computer graphics system for reconstruction from serial section micrographs was applied to intracellular details of a yeast target cell (Saccharomyces cerevisiae cell) induced by the alpha factor mating pheromone and was also applied to a periodontal structure of a dog tooth moved orthodontically. In the former, intracellular organelles and a distribution(More)
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