Masaki Iizuka

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OBJECTIVE Resistin-like molecule (RELM) β is a secretory protein homologous to resistin and reportedly contributes to local immune response regulation in gut and bronchial epithelial cells. However, we found that activated macrophages also express RELMβ and thus investigated the role of RELMβ in the development of atherosclerosis. APPROACH AND RESULTS It(More)
Nociceptive transduction in inflammatory and neuropathic pain involves peripherally expressed voltage-gated sodium channels, such as tetrodotoxin (TTX)-sensitive PN1 and TTX-resistant PN3. We generated recombinant cell lines stably expressing the human PN1 and PN3 sodium channels in Chinese hamster ovary (CHO) cells using inducible expression vectors. The(More)
Resistin-like molecule β (RELMβ) reportedly has multiple functions including local immune responses in the gut. In this study, we investigated the possible contribution of RELMβ to non-alcoholic steatohepatitis (NASH) development. First, RELMβ knock-out (KO) mice were shown to be resistant to methionine-choline deficient (MCD) diet-induced NASH development.(More)
R esistin was initially identified as an adipocyte-secreted factor that causes insulin resistance. 1 Subsequent studies have suggested its association with type 2 diabetes mel-litus, 2 congestive heart failure, 3 and coronary artery disease. After the discovery of resistin, 3 resistin-related proteins, termed resistin-like molecule (RELM) α, β (FIZZ2,(More)
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