Masakazu Matsuzaki

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Effects of acute and chronic administration of phencyclidine (PCP) on both neocortical and subcortical visual potentials (VEPs) and on spontaneous EEGs were studied in the rhesus monkeys with permanently implanted brain electrodes. VEPs were evoked by brief single photo-stimulator flashes (0.8 pps. 10 microsec duration). Injection of PCP (0.5 to 4.0 mg/kg(More)
BACKGROUND Therapeutic hypothermia for comatose survivors of out-of-hospital cardiac arrest has demonstrated neurological benefits. Although early cooling during cardiac arrest enhances efficacy in animal studies, few clinical studies are available. METHODS AND RESULTS The 171 patients who failed to respond to conventional cardiopulmonary resuscitation(More)
Administration of delta 9-tetrahydrocannabinol (THC; 0.75-4.0 mg/kg IP) to rhesus monkeys produced a biphasic pattern of high-voltage slow waves (HVSW) and fast waves (HVFW) EEG, along with behavioral depression and alertness, respectively. The HVSW phase appeared 20 to 30 min after drug injection and was uniquely characterized by spike-bursts in frontal(More)
The effects of chronic administration of high doses of cocaine were studied in monkeys (Ss) with electrodes implanted in the brain. The Ss were injected daily with cocaine at a minimal convulsant dose (MCD) during polygraphic recording of EEGs, eye movement, respiratory and heart rates. The initial cocaine MCDs ranged from 3.2 to 6.5 mg/kg i.v. in ten Ss(More)
The effects of cocaine and pseudococaine on the EEGs, heart and respiratory rates, and self-administration behavior were studied in rhesus monkeys. An intravenous injection of cocaine (2.5 and 4.0 mg/kg) in the monkey produced low-voltage fast waves (LVFWs) in the EEGs and behavioral hyperexcitation accompanied by marked increases in the heart and(More)
Effects of acute and chronic administration of phencyclidine (PCP) on EEG activities and gross behavior were studied in monkeys with electrodes implanted in the brain. Administration of PCP (2.0 or 4.0 mg/kg i.v.) in monkeys produced a biphasic pattern of inhibition and excitation of behavior during 6-8 h observation period. The inhibitory phase appeared(More)
Effects of phencyclidine (PCP) on eliciting afterdischarges (AD) by electrical stimulation of the hippocampus (HIPP), amygdala (AMY), thalamus (CM) and midbrain reticular formation (MRF) were studied in rhesus monkeys with permanently implanted encephalic electrodes. Prior to drug administration, the minimal amount of electrical stimulation for eliciting(More)
The convulsant effects of cocaine and its C2-epimer, pseudococaine on EEG, respiration, heart rate and behavior were studied in the rhesus monkeys with electrodes implanted in the brain. Intravenous injections of cocaine (3.0 to 8.0 mg/kg) and pseudococaine (3.0 to 7.0 mg/kg) in the animals produced a similar pattern of clonic convulsions accompanied by(More)
The effects of cocaine and its dextroisomer pseudococaine on electrical after-discharge (AD) evoked by electrical stimulation of the hippocampus or amygdala were studied in cats with electrodes implanted in the brain. Intravenous injection of cocaine (2.0 to 4.0 mg/kg doses) produced a suppressive effect on the AD while producing low-voltage fast waves(More)